(8S,9R,10S,13R,14S)-17-[(E)-3,3-dihydroxyprop-1-enyl]-13-methyl-10-[(4-pyridin-3-ylphenyl)methyl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,9R,10S,13R,14S)-17-[(E)-3,3-dihydroxyprop-1-enyl]-13-methyl-10-[(4-pyridin-3-ylphenyl)methyl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₃₃H₃₉NO₃
• 分子量: 497.7
• InChiKey: YODAYVHLCIKYIM-VYPVTAPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• FORMULATIONS AND METHODS FOR VAGINAL DELIVERY OF ANTIPROGESTINS
  申请人：Repros Therapeutics Inc.

  公开号：EP2854763A1

  公开（公告）日：2015-04-08
• METHODS AND COMPOSITIONS FOR TREATING PROGESTERONE-DEPENDENT CONDITIONS
  申请人：Repros Therapeutics Inc.

  公开号：EP2914268A1

  公开（公告）日：2015-09-09
• CONDITIONALLY ACTIVE HETERODIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：EP3399991A1

  公开（公告）日：2018-11-14
• [EN] FORMULATIONS AND METHODS FOR VAGINAL DELIVERY OF ANTIPROGESTINS<br/>[FR] FORMULATIONS ET MÉTHODES D'ADMINISTRATION VAGINALE D'ANTIPROGESTINES
  申请人：REPROS THERAPEUTICS INC

  公开号：WO2013181449A1

  公开（公告）日：2013-12-05

  The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule comprising one or more antiprogestins.
• [EN] METHODS AND COMPOSITIONS FOR TREATING PROGESTERONE-DEPENDENT CONDITIONS<br/>[FR] MÉTHODES ET COMPOSITIONS DE TRAITEMENT D'AFFECTIONS DÉPENDANT DE LA PROGESTÉRONE
  申请人：REPROS THERAPEUTICS INC

  公开号：WO2014070517A1

  公开（公告）日：2014-05-08

  The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. Methods for treating these conditions are provided comprising systemically administering an antiprogestin and contemporaneously locally administering an antiprogestin. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.