Acetic acid;(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-phenylmethanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: Acetic acid;(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-phenylmethanamine
• 英文别名: acetic acid;(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-phenylmethanamine
• 化学式: C20H25NO3
• 分子量: 327.4
• InChiKey: SUVMTKVCWWKBME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING DRUG ADDICTION AND PREVENTING A DRUG RELAPSE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES DE TRAITEMENT D'UNE PHARMACODÉPENDANCE ET DE PRÉVENTION À UNE RECHUTE MÉDICAMENTEUSE
  申请人：UNIV ARIZONA

  公开号：WO2013188465A2

  公开（公告）日：2013-12-19

  The present invention relates to pharmaceutical compositions comprising (a) a pharmaceutically effective amount of an mGluR5 positive allosteric modulator, derivative, prodrug or a pharmaceutically acceptable salt thereof; (b) a pharmaceutically effective amount of an agent selected from an NMDA partial agonist or a GlyT1 inhibitor, derivative, prodrug or a pharmaceutically acceptable salt thereof; and (c) a pharmaceutically acceptable carrier. The present invention also relates to methods for treating drug addiction and preventing a drug relapse in a patient. The methods comprise (a) administering to the patient a pharmaceutically effective amount of an mGluR5 positive allosteric modulator, derivative, prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof; (b) administering to the patient a pharmaceutically effective amount of an agent selected from an NMDA partial agonist or a GlyT1 inhibitor, derivative, prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof.