Cyclooct-2-yn-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Cyclooct-2-yn-1-amine
• 英文别名: cyclooct-2-yn-1-amine
• 化学式: C₈H₁₃N
• 分子量: 123.2
• InChiKey: NGKWJWXSMXOXLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] CARBOPYRONONE COMPOUNDS USEFUL AS DIAGNOSTIC ADJUVANTS<br/>[FR] COMPOSÉS CARBOPYRONINE UTILES EN TANT QU'ADJUVANTS DE DIAGNOSTIC
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2015175870A1

  公开（公告）日：2015-11-19

  Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.

  本文描述了荧光化合物及包括这些化合物的方法。本文披露的化合物是在UV/VIS光谱的红色部分发出荧光的羧基吡咯烷试剂，具有明亮的荧光强度、均匀的细胞染色以及在活细胞内良好的保留性，同时对细胞具有低毒性。
• [EN] PHOTOCLEAVABLE DRUG CONJUGATES<br/>[FR] CONJUGUÉS DE MÉDICAMENT PHOTOCLIVABLES
  申请人：UNIV MISSOURI

  公开号：WO2014004278A1

  公开（公告）日：2014-01-03

  Novel photocleavable drug conjugates for forming drug depots comprise drugs attached to photocleavable groups. In one embodiment, the drug is linked via photocleavable group(s) to a polymer chain to form a photocleavable drug-polymer conjugate that generally forms the depot matrix. In another embodiment, the drug is crosslinked via photocleavable group(s) to themselves to form a photocleavable drug conjugate that generally forms the depot.

  新型光解药物结合物用于形成药物库，包括将药物连接到光解基团。在一个实施例中，药物通过光解基团连接到聚合物链，形成光解药物-聚合物结合物，通常形成库基质。在另一个实施例中，药物通过光解基团交联到自身，形成光解药物结合物，通常形成库。
• CELL TRACKING REAGENTS AND THEIR METHODS OF USE
  申请人：LIFE TECHNOLOGIIES CORPORATION

  公开号：US20170044372A1

  公开（公告）日：2017-02-16

  Described herein are compounds, methods, and kits for short- and long-term tracking of cell proliferation, differentiation, and/or function. The compounds disclosed herein are rhodamine-based cell-tracking reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.

  本文描述了一种用于短期和长期跟踪细胞增殖、分化和/或功能的化合物、方法和试剂盒。本文披露的化合物是基于罗丹明的细胞跟踪试剂，其在紫外/可见光谱的红色部分发出荧光，并且具有明亮的荧光强度、均匀的细胞染色以及在活细胞内良好的保留性，同时对细胞具有低毒性。
• METHODS AND COMPOSITIONS FOR DETECTING OR MEASURING CASPASES OR APOPTOSIS
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20190309341A1

  公开（公告）日：2019-10-10

  Provided herein are compounds, enzyme substrates, compositions, kits, uses, and methods for detecting the presence or absence of a caspase enzyme, measuring the activity of a caspase enzyme, or detecting the presence or absence of apoptosis. The detection or measurement can occur through intracellular cleavage of a compound or enzyme substrate, which can lead to an increase in fluorescence, e.g., in the violet or red channel, through liberation of a nucleic acid binding dye from a peptide, such as liberation of a DNA-binding dye from a negatively charged peptide comprising a sequence recognized and cleaved by a caspase

  本文提供了用于检测caspase酶的存在或缺失、测量caspase酶活性或检测凋亡的化合物、酶底物、组合物、试剂盒、用途和方法。检测或测量可以通过化合物或酶底物的细胞内裂解进行，这可以通过从肽中释放核酸结合染料（例如从带有被caspase酶识别和裂解的序列的负电荷肽中释放DNA结合染料）来导致荧光增加，例如在紫色或红色通道中。
• METHODS AND COMPOSITIONS FOR ASSESSING CELL VIABILITY
  申请人：Life Technologies Corporation

  公开号：US20190195801A1

  公开（公告）日：2019-06-27

  Provided herein are compounds, compositions, kits, uses, and methods for assessing the viability of cells and/or quantifying the amount of live and dead cells in a mixture using differential stains. In some embodiments, the compounds are used in culture media or can function independently of fixation and/or permeabilization. In some embodiments, the compounds comprise a platinum atom. In some embodiments, the compounds comprise a nitrogen mustard moiety.

  本文提供了使用差异染色剂评估细胞存活能力和/或量化混合物中的活细胞和死细胞数量的化合物、组合物、试剂盒、用途和方法。在某些实施例中，这些化合物用于培养基或可以独立于固定和/或渗透化功能。在某些实施例中，这些化合物包括铂原子。在某些实施例中，这些化合物包括氮芥基团。