Butane-1,4-diol;1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Butane-1,4-diol;1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane
• 英文别名: butane-1,4-diol;1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane
• 化学式: C19H32N2O4
• 分子量: 352.5
• InChiKey: OKXWJWAEFDDCHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.92
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Bioabsorbable polymer blends
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：US10023738B2

  公开（公告）日：2018-07-17

  The invention provides a bioabsorbable blend of (i) a polymer component comprising polylactic acid (PLA), polyglycolic acid (PGA), a copolymer of PLA and PGA, or any combination thereof and (ii) thermoplastic polyurethane (TPU) tailored to a medical application, and a process for making the same. In some embodiments, the TPU comprises units derived from a diol chain extender, a diisocyanate, and a polyol formulated to provide a set biodegradation rate in combination with at least one physical property. The blend of the invention provides useful materials for medical applications that have the individual benefits of polylactic acid and TPU while moderating each material's typical limitations.

  本发明提供了一种生物可吸收混合物，该混合物包含(i)由聚乳酸(PLA)、聚乙醇酸(PGA)、PLA 和 PGA 的共聚物或其任意组合组成的聚合物成分和(ii)专为医疗应用定制的热塑性聚氨酯(TPU)，以及制造该混合物的工艺。在某些实施例中，热塑性聚氨酯包括由二元醇扩链剂、二异氰酸酯和多元醇衍生的单元，其配制目的是结合至少一种物理特性提供设定的生物降解率。本发明的混合物为医疗应用提供了有用的材料，既具有聚乳酸和热塑性聚氨酯的各自优点，又缓和了每种材料的典型局限性。
• METHOD FOR IDENTIFYING BIOABSORBABLE POLYMERS
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：EP2864386A1

  公开（公告）日：2015-04-29
• BIOABSORBABLE POLYMER BLENDS
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：EP2914641A1

  公开（公告）日：2015-09-09
• [EN] METHOD FOR IDENTIFYING BIOABSORBABLE POLYMERS<br/>[FR] PROCÉDÉ D'IDENTIFICATION DE POLYMÈRES BIOABSORBABLES
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2014004333A1

  公开（公告）日：2014-01-03

  A system and method for producing a bioabsorbable thermoplastic polyurethane tailored to a medical application are provided. The method includes identifying suitable thermoplastic polyurethane properties based on the medical application. The thermoplastic polyurethane comprises units derived from a diol chain extender, a diisocyanate, and a polyol. The thermoplastic polyurethane properties include a biodegradation rate and at least one physical property. The method includes identifying a base thermoplastic polyurethane and altering at least one parameter of the base thermoplastic polyurethane which relates to the desired thermoplastic polyurethane properties to generate a candidate thermoplastic polyurethane. The altering may be performed iteratively until the suitable range of thermoplastic polyurethane properties based on the medical application is met.
• [EN] PROCESS FOR MAKING BIODEGRADABLE AND/OR BIOABSORBABLE POLYMERS<br/>[FR] PROCÉDÉ DE FABRICATION DE POLYMÈRES BIODÉGRADABLES ET/OU BIOABSORBABLES
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2014004334A1

  公开（公告）日：2014-01-03

  A process for producing a bioabsorbable thermoplastic polyurethane tailored to a medical application is provided. The process includes identifying suitable thermoplastic polyurethane properties based on the medical application. The thermoplastic polyurethane comprises units derived from a diol chain extender, a diisocyanate, and a polyol. The thermoplastic polyurethane properties include a biodegradation rate and at least one physical property. The process can include identifying a base thermoplastic polyurethane and altering at least one parameter of the base thermoplastic polyurethane which relates to the desired thermoplastic polyurethane properties to generate a thermoplastic polyurethane.