4-(propylamino)quinazoline | 22754-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(propylamino)quinazoline
• 英文别名: 4-n-Propylaminochinazolin；propyl-quinazolin-4-yl-amine；N-Propylquinazolin-4-amine
• CAS: 22754-05-8
• 化学式: C₁₁H₁₃N₃
• mdl: MFCD12761807
• 分子量: 187.244
• InChiKey: CQFLMYQMMLKNSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(propylamino)quinazoline 、 甲基锂 生成 2-methyl-N-propyl-1,2-dihydroquinazolin-4-amine
  参考文献：
  名称：

  JOHANNSEN, FRANK;PEDERSEN, ERIK B., CHEM. SCR., 27,(1987) N 2, 277-281

  摘要：

  DOI：
• 作为产物：
  描述：

  正丙胺 、 4-(trichloromethyl)quinazoline 以 乙腈 为溶剂， 反应 3.0h， 以96%的产率得到4-(propylamino)quinazoline
  参考文献：
  名称：

  Reactions of 4-(trihalomethyl)quinazolines with aliphatic amines. Role of the halogen atom and of the amine on the reaction pattern

  摘要：

  DOI：

  10.1021/jo00289a070

文献信息

• [EN] ANTI-CANCER AND ANTI-HIV COMPOUNDS<br/>[FR] COMPOSÉS ANTICANCÉREUX ET ANTI-VIH
  申请人：SIRENAS MARINE DISCOVERY

  公开号：WO2014123900A1

  公开（公告）日：2014-08-14

  Disclosed herein are compounds useful as anti-cancer and anti-HIV agents. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds disclosed herein can be used to treat a variety of conditions, diseases and ailments such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer, and HIV related disorders.

  本文披露了作为抗癌和抗HIV药物有用的化合物。还披露了药物组合物和治疗方法。本文披露的化合物可用于治疗多种疾病和疾病，如膀胱癌、乳腺癌、结肠癌、直肠癌、子宫内膜癌、肾癌、肺癌、黑色素瘤、非霍奇金淋巴瘤、胶质母细胞瘤、胰腺癌、前列腺癌和甲状腺癌，以及HIV相关疾病。
• Synthesis of Fused Polycyclic 4‐Anilinoquinazolines and <i>N</i> ‐Quinazoline‐Indoles <i>via</i> Selective C−H Bond Activation
  作者：Xin‐Yang Liu、Hao Liu、Xian‐Zhang Liao、Lin Dong、Fen‐Er Chen

  DOI：10.1002/adsc.202000895

  日期：2020.12.22

  An efficient rhodium(III)‐catalyzed site‐selective functionalization of 4‐anilinoquinazolines offers exciting possibilities for fused polycyclic 4‐anilinoquinazoline derivatives and N‐quinazoline‐indoles by using diazo compounds as the elegant coupling partners. This one‐pot cascade approach to establish various complex 4‐anilinoquinazoline units with potential biological activities only depends on

  通过使用重氮化合物作为优雅的偶联伙伴，高效的铑（III）催化4-苯胺基喹唑啉的位点选择性官能化为稠合多环4-苯胺基喹唑啉衍生物和N-喹唑啉吲哚提供了令人兴奋的可能性。这种单罐级联方法可以建立具有潜在生物活性的各种复杂的4-苯胺基喹唑啉单元，仅取决于底物和添加剂。
• JOHANNSEN, FRANK;PEDERSEN, ERIK B., CHEM. SCR., 27,(1987) N 2, 277-281
  作者：JOHANNSEN, FRANK、PEDERSEN, ERIK B.

  DOI：——

  日期：——
• GDF-8 INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2903978B1

  公开（公告）日：2022-12-07
• CURABLE COMPOSITION COMPRISING A THERMOLATENT BASE
  申请人：Nesvadba Peter

  公开号：US20110245375A1

  公开（公告）日：2011-10-06

  The present invention relates to curable compositions comprising a thermolatent amidine base and an organic material which is polymerisable or crosslinkable with a basic or nucleophilic catalyst. In particular, the invention relates to curable coating compositions, especially powder coating compositions, and curable adhesive compositions, as well as to the use a thermo-latent amidine base as a curing catalyst for thermally induced base- catalyzed polymerisation or crosslinking reactions.