N-(methoxymethyl)cyclopropanamine;hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(methoxymethyl)cyclopropanamine;hydrochloride
• 化学式: C5H12ClNO
• 分子量: 137.61
• InChiKey: PGFPVPSNYMPZOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3551627A1

  公开（公告）日：2019-10-16
• [EN] FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS D'ACIDE GRAS SYNTHASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2014008223A2

  公开（公告）日：2014-01-09

  This invention relates to novel spirocyclic piperidines according to Formula (I) which are inhibitors of fatty acid synthase (FAS), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.
• [EN] NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM<br/>[FR] NOUVEAUX DÉRIVÉS D'ÉTHER ISOXAZOLYLE EN TANT QUE GABA A ALPHA5 PAM
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018104419A1

  公开（公告）日：2018-06-14

  The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.