(4R,7aR,12bS)-10,11-dichloro-4a,9-dihydroxy-3-methyl-2,4,7a,10,11,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (4R,7aR,12bS)-10,11-dichloro-4a,9-dihydroxy-3-methyl-2,4,7a,10,11,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
• 化学式: C₁₇H₁₇Cl₂NO₄
• 分子量: 370.2
• InChiKey: NXJLAGSQRDJMCE-RGOJGMJISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] PROCESS FOR IMPROVED OPIOID SYNTHESIS<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE AMÉLIORÉE D'OPIOÏDES
  申请人：RHODES TECHNOLOGIES

  公开号：WO2014013313A1

  公开（公告）日：2014-01-23

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  用作制备阿片类药物的起始物质或中间物质的化合物和组合物，例如氧吗啡基和/或氧吗啡盐; 制备这些化合物和组合物的过程; 在制备API和制药剂量形式中使用这些化合物和组合物的用途; 以及在治疗医疗状况中使用所述API和制药剂量形式的用途。
• PROCESS FOR IMPROVED OPIOID SYNTHESIS
  申请人：RHODES TECHNOLOGIES

  公开号：US20150315203A1

  公开（公告）日：2015-11-05

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  化合物和组合物可用作制备阿片类药物的起始物质或中间物质，例如氧吗啡基和/或氧吗啡盐；制备这些化合物和组合物的过程；这些化合物和组合物在制备API和制药剂量形式中的用途；以及所述API和制药剂量形式在治疗医疗状况中的用途。
• Process for improved opioid synthesis
  申请人：RHODES TECHNOLOGIES

  公开号：US10316042B2

  公开（公告）日：2019-06-11

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  用作制备阿片类药物的起始原料或中间原料的化合物和组合物，包括氧吗啡酮碱和/或氧吗啡酮盐；制备这些化合物和组合物的工艺；这些化合物和组合物在制备原料药和药物剂型中的用途；以及上述原料药和药物剂型在治疗疾病中的用途。