4-[6-[1-(1H-1,2,4-triazol-5-yl)butyl]-1,3-benzothiazol-2-yl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-[6-[1-(1H-1,2,4-triazol-5-yl)butyl]-1,3-benzothiazol-2-yl]benzoic acid
• 化学式: C₂₀H₁₈N₄O₂S
• 分子量: 378.4
• InChiKey: KHWAQUVRESXCLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES DYSPROLIFÉRATIVES
  申请人：ANGION BIOMEDICA CORP

  公开号：WO2014015137A2

  公开（公告）日：2014-01-23

  Methods are provided for treating cancer and other dysproliferative diseases by administering to a subject in need there of a therapeutically effective amount of a synergistic composition comprising an HER2 inhibitor, or a pharmaceutically acceptable salt or prodrug thereof; and a CYP26 inhibitor, or a pharmaceutically acceptable salt or prodrug thereof; wherein said therapeutically effective amount suppresses the growth of dysproliferative cells in vivo. Compositions comprising a combination of an HER2 inhibitor, or a pharmaceutically acceptable salt or prodrug thereof; and a CYP26 inhibitor a pharmaceutically acceptable salt or prodrug thereof are also described.
• [EN] COMPOSITIONS AND METHODS FOR TREATING DISEASE<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIE
  申请人：ANGION BIOMEDICA CORP

  公开号：WO2014093960A1

  公开（公告）日：2014-06-19

  Methods are provided for treating fibrotic diseases and conditions and cancer and other dysproliferative diseases by administering to a subject in need there of a therapeutically effective amount of a composition comprising a retinol, or a pharmaceutically acceptable ester, salt or prodrug thereof; and a CYP26 inhibitor, or a pharmaceutically acceptable ester, salt or prodrug thereof; wherein said therapeutically effective amount suppresses fibrosis or the growth of dysproliferative cells in vivo. Compositions comprising a combination of a retinol, or a pharmaceutically acceptable ester, salt or prodrug thereof; and a CYP26 inhibitor a pharmaceutically acceptable ester, salt or prodrug thereof are also described.