7-Bromo-1-trifluoromethyl-2-(4-trifluoromethyl-cyclohexyloxy)-naphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-Bromo-1-trifluoromethyl-2-(4-trifluoromethyl-cyclohexyloxy)-naphthalene
• 英文别名: 7-bromo-1-(trifluoromethyl)-2-[4-(trifluoromethyl)cyclohexyl]oxynaphthalene
• 化学式: C₁₈H₁₅BrF₆O
• 分子量: 441.2
• InChiKey: IFWOPQPISILTAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-Bromo-1-trifluoromethyl-2-(4-trifluoromethyl-cyclohexyloxy)-naphthalene 、 Methyl 9-azabicyclo[3.3.1]nonane-3-carboxylate 、 potassium carbonate 、 、 二氯甲烷 、 1,4-二氧六环 在 一氧化碳 、 CO 、 乙酸乙酯 、 Brine 、 ethyl acetate heptane 作用下， 反应 2.0h， 以to give desired product as a colorless gel (36 mg, 14%)的产率得到9-[7-(4-Trifluoromethyl-cyclohexyloxy)-8-trifluoromethyl-naphthalene-2-carbonyl]-9-aza-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester
  参考文献：
  名称：

  ATX MODULATING AGENTS

  摘要：

  本发明公开了式（I）的双环芳基化合物，可以调节自体移行素（ATX）酶的活性。本发明还涉及ATX抑制剂化合物以及制备和使用这种化合物治疗因损伤或疾病引起的脱髓鞘和治疗增生性疾病如癌症的方法。

  公开号：

  US20150210647A1

文献信息

• ATX modulating agents
  申请人：BIOGEN MA INC.

  公开号：US10017506B2

  公开（公告）日：2018-07-10

  Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.

  本发明公开了式(I)的双环芳基化合物，它们可以调节自体免疫球蛋白(ATX)酶的活性。本发明进一步涉及作为 ATX 抑制剂的化合物，以及制造和使用此类化合物治疗因损伤或疾病引起的脱髓鞘以及治疗癌症等增殖性疾病的方法。
• 1-[7-(cis-4-methyl-cyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid derivatives as autotaxin (ATX) modulators for treating inflammations and autoimmune disorders
  申请人：Biogen MA Inc.

  公开号：EP2877166B1

  公开（公告）日：2018-02-28
• US9522889B2
  申请人：——

  公开号：US9522889B2

  公开（公告）日：2016-12-20
• [EN] ATX MODULATING AGENTS<br/>[FR] AGENTS DE MODULATION D'ATX
  申请人：BIOGEN IDEC INC

  公开号：WO2014018881A1

  公开（公告）日：2014-01-30

  Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
• ATX MODULATING AGENTS
  申请人：BIOGEN IDEC MA INC.

  公开号：US20150210647A1

  公开（公告）日：2015-07-30

  Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.

  本发明公开了式（I）的双环芳基化合物，可以调节自体移行素（ATX）酶的活性。本发明还涉及ATX抑制剂化合物以及制备和使用这种化合物治疗因损伤或疾病引起的脱髓鞘和治疗增生性疾病如癌症的方法。