[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] furan-2-carboxylate;[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] propanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] furan-2-carboxylate;[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] propanoate
• 化学式: C58H68F6O13S2
• 分子量: 1151.3
• InChiKey: JSCHCLKBDZOIHR-ORUNSDQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.28
• 重原子数：
  79
• 可旋转键数：
  18
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  237
• 氢给体数：
  0
• 氢受体数：
  21

文献信息

• [EN] PHARMACEUTICAL COMPOSITION<br/>[FR] COMPOSITION PHARMACEUTIQUE
  申请人：CIPLA LTD

  公开号：WO2014016548A2

  公开（公告）日：2014-01-30

  The present invention relates to pharmaceutical compositions for inhalation which comprise one or more bronchodilators and an inhaled corticosteroid. More particularly, the present invention relates to pharmaceutical compositions comprising olodaterol, an inhaled corticosteroid and/or an anticholinergic agent. The present invention also relates to a process for preparing the pharmaceutical composition and use thereof in the treatment and/or prevention of respiratory, inflammatory or obstructive airway disease.