3-[5-(Azepan-1-yl)pentyl]-5-butylpyrazolo[4,3-d]pyrimidin-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 3-[5-(Azepan-1-yl)pentyl]-5-butylpyrazolo[4,3-d]pyrimidin-1-amine
• 英文别名: 3-[5-(azepan-1-yl)pentyl]-5-butylpyrazolo[4,3-d]pyrimidin-1-amine
• 化学式: C₂₀H₃₄N₆
• 分子量: 358.5
• InChiKey: DLAVUFGGEXVYEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRAZOLOPYRIMIDINE COMPOUNDS
  申请人：GlaxoSmithKline LLC

  公开号：EP2888264A1

  公开（公告）日：2015-07-01
• [EN] PYRAZOLOPYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS PYRAZOLOPYRIMIDINE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2014031815A1

  公开（公告）日：2014-02-27

  Compounds of formula (I) and salts thereof : wherein R1 is n-C1-6alkyl or C1-2alkoxyC1-2alkyl-, R2 is halo, OH or C1-3alkyl, m is an integer having a value of 4, 5, 6 or 7, n is an integer having a value of 0, 1, 2 or 3, and p is an integer having a value of 0, 1 or 2, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.