3-Benzyl-7-(1-bromocycloprop-2-en-1-yl)-8-methoxypyrazolo[3,4-c]isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 3-Benzyl-7-(1-bromocycloprop-2-en-1-yl)-8-methoxypyrazolo[3,4-c]isoquinoline
• 英文别名: 3-benzyl-7-(1-bromocycloprop-2-en-1-yl)-8-methoxypyrazolo[3,4-c]isoquinoline
• 化学式: C₂₁H₁₆BrN₃O
• 分子量: 406.3
• InChiKey: CMZXGRWGTHHOLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• AMINOISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
  申请人：Eternity Bioscience Inc.

  公开号：EP2895166A1

  公开（公告）日：2015-07-22
• [EN] AMINOISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'AMINOISOQUINOLINE UTILISABLES EN TANT QU'INHIBITEURS DES PROTÉINES KINASES
  申请人：ETERNITY BIOSCIENCE INC

  公开号：WO2014043296A1

  公开（公告）日：2014-03-20

  The present invention provides novel aminoisoquinoline compounds as defined in the specification, compositions thereof, use of these compounds as protein kinase inhibitors and as therapeutic agents for treatment of Raf kinase, in particular BRAFV600E kinase, related diseases or disorders, such as cancers. In addition, the invention also includes methods and processes for preparing these novel aminoisoquinoline compounds.