6-iodo-2,3-dimethylquinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-iodo-2,3-dimethylquinazolin-4-one
• 英文别名: 6-iodo-2,3-dimethylquinazolin-4(3H)-one
• 化学式: C₁₀H₉IN₂O
• 分子量: 300.099
• InChiKey: POBHURHUKAAEKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for producing pyrimidin-4-one compound
  申请人：Nishino Shigeyoshi

  公开号：US20060270849A1

  公开（公告）日：2006-11-30

  A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions.

  在相对简单和温和的反应条件下，在含有氮原子的化合物的存在下，通过将氨基芳基羧酸化合物与有机酸化合物反应，可以高产率地制备一种嘧啶-4-酮化合物。
• Pyrimidinylpyrazoles as Tgf-Beta Inhibitors
  申请人：Lee Wen-Cherng

  公开号：US20080171755A1

  公开（公告）日：2008-07-17

  The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).

  该发明基于发现，公式（I）化合物具有高亲和力与Alk 5和/或Alk 4，并可用作其拮抗剂，用于预防和/或治疗多种疾病，包括纤维化疾病。该发明涉及公式（I）的化合物及其用途：公式（I）。
• PLATELET ADP RECEPTOR INHIBITORS
  申请人：Scarborough Robert M.

  公开号：US20100234350A1

  公开（公告）日：2010-09-16

  Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

  式（I）到（VIII）的新化合物，其中更特别包括磺酰脲衍生物、磺酰硫脲衍生物、磺酰胍衍生物、磺酰氰胍衍生物、硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物，它们是有效的血小板ADP受体抑制剂。这些衍生物可以用于各种药物组合物中，特别是对于预防和/或治疗心血管疾病，特别是与血栓有关的疾病非常有效。本发明还涉及一种预防或治疗哺乳动物中血栓形成的方法，包括给予化合物式（I）到（VIII）或其药学上可接受的盐的治疗有效量的步骤。
• PROCESS FOR PRODUCING PYRIMIDIN-4-ONE COMPOUND
  申请人：Ube Industries, Ltd.

  公开号：EP1637523A1

  公开（公告）日：2006-03-22

  A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions.

  在相对简单和温和的反应条件下，氨基芳基羧酸化合物与有机酸化合物在含氮原子的化合物存在下发生反应，可以高产率制备嘧啶-4-酮化合物。
• US8067428B2
  申请人：——

  公开号：US8067428B2

  公开（公告）日：2011-11-29