(5Z)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-[4-[(5Z)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]piperazin-1-yl]-1,3-thiazol-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (5Z)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-[4-[(5Z)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]piperazin-1-yl]-1,3-thiazol-4-one
• 化学式: C₂₆H₂₄N₄O₆S₂
• 分子量: 552.6
• InChiKey: HXWHTENFBMLRKJ-JZTLMNBPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  175
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE
  申请人：CARDOZO Timothy

  公开号：US20110288083A1

  公开（公告）日：2011-11-24

  The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases.
• US9198891B2
  申请人：——

  公开号：US9198891B2

  公开（公告）日：2015-12-01