6-propan-2-yl-3,4-dihydro-1H-quinazolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-propan-2-yl-3,4-dihydro-1H-quinazolin-2-one
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.24
• InChiKey: GEVUHIJGOCTMTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX KINASE ("NACK") AND METHODS FOR USE OF THE SAME<br/>[FR] INHIBITEURS DE LA KINASE COMPLEXE D'ACTIVATION TRANSCRIPTIONNELLE NOTCH ("NACK") ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV MIAMI

  公开号：WO2019157065A9

  公开（公告）日：2022-10-06
• METHODS FOR THE SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
  申请人：Verdine Gregory L.

  公开号：US20140194610A1

  公开（公告）日：2014-07-10

  Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.
• INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX KINASE ("NACK") AND METHODS FOR USE OF THE SAME
  申请人：UNIVERSITY OF MIAMI

  公开号：US20210171469A1

  公开（公告）日：2021-06-10

  Disclosed herein are Notch transcriptional activation complex kinase (“NACK”) inhibitors, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein include compounds of Formula (la) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
• [EN] COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：NEUROP INC

  公开号：WO2013170072A2

  公开（公告）日：2013-11-14

  In one aspect, the invention relates to NMDA receptor modulators, derivatives thereof, and related compounds, which are useful as inhibitors of the NMDA receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating or preventing neurological and psychiatric disorders associated with NMDA receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.