N-(3-chloro-4-methylphenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(3-chloro-4-methylphenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
• 化学式: C₂₃H₂₇ClN₄O₃
• 分子量: 442.9
• InChiKey: VXPBWPWTSVUTPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  68.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• IONIC LIQUID SUPPORTED ORGANOTIN REAGENTS FOR THE MANUFACTURING OF RADIOPHARMACEUTICALS COMPOUNDS
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP3092243B1

  公开（公告）日：2019-06-19
• PHARMACEUTICAL COMBINATIONS FOR TREATMENT OF SPECIFIC CANCERS
  申请人：ARDEA BIOSCIENCES, INC.

  公开号：US20140080783A1

  公开（公告）日：2014-03-20

  The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.
• US9220696B2
  申请人：——

  公开号：US9220696B2

  公开（公告）日：2015-12-29
• US9714261B2
  申请人：——

  公开号：US9714261B2

  公开（公告）日：2017-07-25