3,3-Difluoro-1-methylcyclobutane-1-carbonitrile

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,3-Difluoro-1-methylcyclobutane-1-carbonitrile
• 英文别名: 3,3-difluoro-1-methylcyclobutane-1-carbonitrile
• 化学式: C₆H₇F₂N
• 分子量: 131.12
• InChiKey: LWXRSDZKQMSNIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL TRPV3 MODULATORS
  申请人：ABBVIE INC.

  公开号：US20140080803A1

  公开（公告）日：2014-03-20

  Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G 1 , X 1 , X 2 , X 3 , X 4 , X 5 , G 2 , Z 1 , R a , R b , and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

  本文披露了TRPV3的调节剂，其化学式为(I)，其中p为1、2、3或4，G1、X1、X2、X3、X4、X5、G2、Z1、Ra、Rb和u的定义如规范中所述。还提供了包含这些化合物的组合物以及使用这些化合物和组合物治疗疾病和疾病的方法。
• Benzyl-, (pyridin-3-yl)methyl -or (pyridin-4-yl)-methyl-substituted oxadiazolopyridine derivatives as ghrelin O-acyl transferase (GOAT) inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US11254688B2

  公开（公告）日：2022-02-22

  The present invention relates to compounds of general formula (I), wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.

  本发明涉及通式(I)的化合物，其中基团 R1 和 R2 的定义如权利要求 1 所述，这些化合物具有重要的药理特性，特别是能与胃泌素 O-酰基转移酶（GOAT）结合并调节其活性。这些化合物适用于治疗和预防受该受体影响的疾病，如代谢性疾病，特别是肥胖症。
• TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210038603A1

  公开（公告）日：2021-02-11

  The present invention relates to compounds of general formula I, wherein the groups R 1 and R 2 are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
• BENZYL-, (PYRIDIN-3-YL)METHYL -OR (PYRIDIN-4-YL)-METHYL-SUBSTIITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210053985A1

  公开（公告）日：2021-02-25

  The present invention relates to compounds of general formula (I), wherein the groups R 1 and R 2 are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
• US8772499B2
  申请人：——

  公开号：US8772499B2

  公开（公告）日：2014-07-08