6,7-dimethoxy-2-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7-dimethoxy-2-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1H-quinazolin-4-one
• 英文别名: 6,7-dimethoxy-2-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3H-quinazolin-4-one
• 化学式: C₂₂H₂₃N₃O₃
• 分子量: 377.4
• InChiKey: CKCSOMMBIPJYSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR TREATMENT OF RETINAL DISEASE
  申请人：University of Washington

  公开号：US20200368234A1

  公开（公告）日：2020-11-26

  Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject using Photoregulin3 (PR3).
• [EN] PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR TREATMENT OF RETINAL DISEASE<br/>[FR] PHOTORÉGULINE 3 DE MODULATEUR DE GÈNE PHOTORÉCEPTEUR POUR LE TRAITEMENT D'UNE MALADIE RÉTINIENNE
  申请人：UNIV WASHINGTON

  公开号：WO2019032999A1

  公开（公告）日：2019-02-14

  Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject using Photoregulin3 (PR3).