2-[Hydroxy(pentadecoxy)phosphoryl]oxyethyl-trimethylazanium | 146801-07-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[Hydroxy(pentadecoxy)phosphoryl]oxyethyl-trimethylazanium
• CAS: 146801-07-2
• 化学式: C20H45NO4P+
• 分子量: 394.5
• InChiKey: HITMISAYDYAKTA-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel alkyl phospholipid derivatives and uses thereof
  申请人：Zentaris GmbH

  公开号：EP1800684A1

  公开（公告）日：2007-06-27

  The present invention provides novel alkyl phospholipid derivatives that are useful for treating various diseases including tumors and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular fungi, protozoa, bacteria and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies, in particular for the treatment of leishmaniasis, trypanosomiasis and/or malaria.

  本发明提供了新型烷基磷脂衍生物，可用于治疗包括肿瘤和/或哺乳动物（尤其是人类）中由微生物，特别是真菌、原虫、细菌和/或病毒引起的各种疾病，这些烷基磷脂可作为单一药物或结合疗法的一部分，特别是用于治疗利什曼病、锥虫病和/或疟疾。
• Detection of membrane proteins
  申请人：Oxford University Innovation Limited

  公开号：US10955421B2

  公开（公告）日：2021-03-23

  A method of detecting a membrane protein by mass spectrometry comprises: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector; wherein the solution contains a phosphate ester detergent which forms said detergent micelle. Also provided are reagents for use in said method.

  一种利用质谱检测膜蛋白的方法包括(a) 提供包含洗涤剂胶束的溶液，其中含有所述膜蛋白； (b) 提供包括纳米电喷雾离子源、质量分析器和检测器的质谱仪； (c) 在使膜蛋白从胶束中释放的条件下，使用纳米电喷雾离子源蒸发溶液；(d) 电离膜蛋白； (e) 使用质量分析器解析电离出的膜蛋白；以及 (f) 使用检测器检测解析出的膜蛋白；其中溶液含有磷酸酯去垢剂，形成所述去垢胶束。还提供了用于所述方法的试剂。
• REFOLDED MEMBRANE PROTEIN IN MONODISPERSE FORM
  申请人：M-Phasys GmbH

  公开号：EP1704163A1

  公开（公告）日：2006-09-27
• NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF
  申请人：PERRISSOUD Daniel

  公开号：US20070167408A1

  公开（公告）日：2007-07-19

  The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.
• DETECTION OF MEMBRANE PROTEINS
  申请人：Oxford University Innovation Limited

  公开号：US20200240997A1

  公开（公告）日：2020-07-30

  A method of detecting a membrane protein by mass spectrometry comprises: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector; wherein the solution contains a phosphate ester detergent which forms said detergent micelle. Also provided are reagents for use in said method.