(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide;1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide;1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
• 化学式: C32H55ClN5O7P
• 分子量: 688.2
• InChiKey: RCPKCSBTZAEZLM-ZNBOUQNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.34
• 重原子数：
  46
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  156
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• MATERIALS AND METHODS USEFUL FOR TREATING GLIOBLASTOMA
  申请人：Ohio State Innovation Foundation

  公开号：EP2919759A1

  公开（公告）日：2015-09-23
• COMBINATION THERAPY OF FRACTIONATED RADIATION AND SAPC-DOPS FOR THE TREATMENT OF TUMORS
  申请人：University of Cincinnati

  公开号：EP3697413A1

  公开（公告）日：2020-08-26
• sGCalpha1 Inhibiting Compositions, and Methods of Treatment of Cancers Therewith
  申请人：The University of Toledo

  公开号：US20140088023A1

  公开（公告）日：2014-03-27

  The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
• Materials and Methods Useful for Treating Glioblastoma
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US20150290300A1

  公开（公告）日：2015-10-15

  The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rapamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.
• Materials and Methods Useful For Treating Glioblastoma
  申请人：Ohio State Innovation Foundation

  公开号：US20170340715A1

  公开（公告）日：2017-11-30

  The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.