3-(2-Bromoethylamino)-2-(1-nitroimidazol-2-yl)propan-1-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(2-Bromoethylamino)-2-(1-nitroimidazol-2-yl)propan-1-ol
• 英文别名: 3-(2-bromoethylamino)-2-(1-nitroimidazol-2-yl)propan-1-ol
• 化学式: C8H13BrN4O3
• 分子量: 293.12
• InChiKey: OAOFJPOEGCSXSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER
  申请人：Karin Michael

  公开号：US20140086939A1

  公开（公告）日：2014-03-27

  The invention provides methods for detecting the presence of cancer initiating cells in a tissue, methods for identifying test agent for reducing cancer, and methods for reducing cancer in a subject. The invention's methods are applicable to any cancer, and in particular to liver cancer. The invention also provides the isolation and characterization of pre-malignant hepatocellular carcinoma initiating cells (HICs). The invention further provides methods for isolating hepatocellular carcinoma initiating cells (HICs), methods for using the isolated cells for screening anti-cancer drugs, methods for using HIC markers for the early diagnosis of hepatocellular carcinoma, and methods for the prevention and/or delay of hepatocellular carcinoma by using agents that selectively deplete the number and/or malignant properties of HICs.