2-(3-Fluorophenyl)-6-[[2-(3-fluorophenyl)-4-oxo-3,1-benzoxazin-6-yl]methyl]-3,1-benzoxazin-4-one | 5770-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2-(3-Fluorophenyl)-6-[[2-(3-fluorophenyl)-4-oxo-3,1-benzoxazin-6-yl]methyl]-3,1-benzoxazin-4-one
• CAS: 5770-90-1
• 化学式: C₂₉H₁₆F₂N₂O₄
• 分子量: 494.4
• InChiKey: ZQMARHJJCQQSGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• HEPSIN INHIBITORS
  申请人：Vasioukhin Valeri I.

  公开号：US20110144139A1

  公开（公告）日：2011-06-16

  Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.
• US8450334B2
  申请人：——

  公开号：US8450334B2

  公开（公告）日：2013-05-28
• US8664266B2
  申请人：——

  公开号：US8664266B2

  公开（公告）日：2014-03-04
• US9182402B2
  申请人：——

  公开号：US9182402B2

  公开（公告）日：2015-11-10
• [EN] HEPSIN INHIBITORS<br/>[FR] INHIBITEURS D'HEPSINE
  申请人：HUTCHINSON FRED CANCER RES

  公开号：WO2009151920A2

  公开（公告）日：2009-12-17

  Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.