(Z)-2-(propan-2-ylideneamino)prop-1-en-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (Z)-2-(propan-2-ylideneamino)prop-1-en-1-amine
• 化学式: C₆H₁₂N₂
• 分子量: 112.17
• InChiKey: KSSOCBRAWRNZGT-XQRVVYSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INHIBITORS OF C-FMS KINASE
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP3208269A1

  公开（公告）日：2017-08-23

  The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

  本发明涉及式 I 的化合物： 其中Z、X、J、R2和W如说明书所述，以及它们的溶解物、水合物、同系物和药学上可接受的盐，可抑制蛋白酪氨酸激酶，特别是c-fms激酶。治疗自身免疫性疾病的方法；治疗具有炎症成分的疾病的方法；治疗卵巢癌、子宫癌、乳腺癌、前列腺癌、肺癌、结肠癌、胃癌、毛细胞白血病转移的方法；治疗疼痛的方法，包括肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏疼痛、炎症疼痛和神经源性疼痛；以及骨质疏松症、Paget's 病和其他骨吸收介导发病的疾病，包括类风湿性关节炎和其他形式的炎症性关节炎、骨关节炎、假体失效、溶骨肉瘤、骨髓瘤和肿瘤骨转移。
• HISTONE DEMETHYLASE INHIBITORS
  申请人：Celgene Quanticel Research, Inc.

  公开号：EP3193881B1

  公开（公告）日：2022-02-09
• US8680120B2
  申请人：——

  公开号：US8680120B2

  公开（公告）日：2014-03-25
• US9416139B2
  申请人：——

  公开号：US9416139B2

  公开（公告）日：2016-08-16