(2,2-Dimethylmorpholin-4-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (2,2-Dimethylmorpholin-4-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
• 英文别名: (2,2-dimethylmorpholin-4-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
• 化学式: C₂₁H₂₁N₇O₂
• 分子量: 403.4
• InChiKey: XFIRFWANDJRIRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  97.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] TETRAZOLO QUINOXALINE DERIVATIVES AS TANKYRASE INHIBITORS<br/>[FR] DÉRIVÉS DE TÉTRAZOLO QUINOXALINE UTILISÉS COMME INHIBITEURS DE LA TANKYRASE
  申请人：CELLZOME GMBH

  公开号：WO2014045101A1

  公开（公告）日：2014-03-27

  The present invention relates to compounds of formula (I), wherein X, R1, y and R 2have the meaning as cited in the description and the claims. Said compounds are useful as tankyrase inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders or diseases, proliferative diseases, neurodegenerative diseases, fibrosis or for inducing cardiomyogenesis. The invention also relates to pharmaceutical compositions including said compounds as well as the use as medicaments.