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3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(naphthalen-1-ylsulfonyl)benzofuran-2-carboxamide | 1585221-68-6

中文名称
——
中文别名
——
英文名称
3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(naphthalen-1-ylsulfonyl)benzofuran-2-carboxamide
英文别名
3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-naphthalen-1-ylsulfonyl-1-benzofuran-2-carboxamide
3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(naphthalen-1-ylsulfonyl)benzofuran-2-carboxamide化学式
CAS
1585221-68-6
化学式
C30H26ClNO5S
mdl
——
分子量
548.059
InChiKey
PARHRPCMYBOTED-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    8
  • 重原子数:
    38
  • 可旋转键数:
    8
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.17
  • 拓扑面积:
    94
  • 氢给体数:
    1
  • 氢受体数:
    5

反应信息

  • 作为产物:
    描述:
    萘-2-磺酰胺 、 3-(3-(4-Chloro-3,5-dimethylphenoxy)propyl)benzofuran-2-carboxylic acid 、 1-萘磺酰胺 生成 3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(naphthalen-1-ylsulfonyl)benzofuran-2-carboxamide
    参考文献:
    名称:
    SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
    摘要:
    本发明提供了一种抑制抗凋亡Bcl-2家族成员髓系细胞白血病-1(Mcl-1)蛋白活性的化合物。本发明还提供了制药组合物以及使用化合物治疗因Mcl-1蛋白过度表达或失调而表现出的疾病和症状(例如癌症)的方法。
    公开号:
    US20150336925A1
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文献信息

  • Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
    申请人:VANDERBILT UNIVERSITY
    公开号:US10093640B2
    公开(公告)日:2018-10-09
    The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
    本发明提供了抑制抗凋亡 Bcl-2 家族成员骨髓细胞白血病-1(Mcl-1)蛋白活性的化合物。本发明还提供了药物组合物以及使用化合物治疗以 Mcl-1 蛋白过度表达或失调为特征的疾病和病症(如癌症)的方法。
  • Chemical entities that kill senescent cells for use in treating age-related disease
    申请人:Unity Biotechnology, Inc.
    公开号:US10195213B2
    公开(公告)日:2019-02-05
    Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
    本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。
  • Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors
    申请人:Vanderbilt University
    公开号:US10844032B2
    公开(公告)日:2020-11-24
    The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
    本发明提供了抑制抗凋亡 Bcl-2 家族成员骨髓细胞白血病-1(Mcl-1)蛋白活性的化合物。本发明还提供了药物组合物以及使用化合物治疗以 Mcl-1 蛋白过度表达或失调为特征的疾病和病症(如癌症)的方法。
  • COMPOUNDS AND THERAPEUTIC USES
    申请人:Unity Biotechnology, Inc.
    公开号:US20170281649A1
    公开(公告)日:2017-10-05
    Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
  • [EN] SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS<br/>[FR] INHIBITEURS DE LA MCL-1 À BASE DE BENZOFURANE, DE BENZOTHIOPHÈNE ET D'INDOLE SUBSTITUÉS
    申请人:UNIV VANDERBILT
    公开号:WO2014047427A2
    公开(公告)日:2014-03-27
    The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
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