3-[(1-Bromopyrrolidin-2-yl)methyl]-5,7-dichloro-8-hydroxyquinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[(1-Bromopyrrolidin-2-yl)methyl]-5,7-dichloro-8-hydroxyquinazolin-4-one
• 英文别名: 3-[(1-bromopyrrolidin-2-yl)methyl]-5,7-dichloro-8-hydroxyquinazolin-4-one
• 化学式: C₁₃H₁₂BrCl₂N₃O₂
• 分子量: 393.1
• InChiKey: OHOJDMVXIUNWNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  56.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD OF TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)
  申请人：Prana Biotechnology Limited

  公开号：US20140088122A1

  公开（公告）日：2014-03-27

  The present invention relates generally to the field of treatment and prophylaxis of retinal degenerative diseases. More particularly, the present invention contemplates a method for preventing, reducing the risk of development of, or otherwise treating or ameliorating the symptoms of, age-related macular degeneration (AMD) or related retinal conditions in mammals and in particular humans. The present invention further provides therapeutic compositions enabling dose-dependent or dose-specific administration of agents useful in the treatment and prophylaxis of age-related macular degeneration or related retinal degenerative conditions.
• US9163018B2
  申请人：——

  公开号：US9163018B2

  公开（公告）日：2015-10-20