[3-[3-[3-[(E)-(aminocarbamothioylhydrazinylidene)methyl]phenoxy]propyl-methylamino]-1-hydroxy-1-phosphonopropyl]phosphonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: [3-[3-[3-[(E)-(aminocarbamothioylhydrazinylidene)methyl]phenoxy]propyl-methylamino]-1-hydroxy-1-phosphonopropyl]phosphonic acid
• 化学式: C₁₅H₂₇N₅O₈P₂S
• 分子量: 499.4
• InChiKey: KOIBCVRMLLXVGE-GZTJUZNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.2
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  242
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• BIFUNCTIONAL HYDROXY-BISPHOSPHONIC ACID DERIVATIVES
  申请人：Egorov Maxim

  公开号：US20140086843A1

  公开（公告）日：2014-03-27

  The present invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) below: or a pharmaceutically-acceptable salt thereof, a method for producing the same, pharmaceutical compositions containing the same, and the use thereof as a medicament, as well as a compound of formula (II) below: or a pharmaceutically-acceptable salt thereof, and the use thereof for producing a vectorized molecule of therapeutic or diagnostic purpose.

  本发明涉及以下式子(I)的双功能羟基双膦酸衍生物或其药学上可接受的盐，以及制备该衍生物的方法，含有该衍生物的药物组合物以及其作为药物的用途，以及以下式子(II)的化合物或其药学上可接受的盐，以及用于生产用于治疗或诊断目的的载体化分子的用途。
• AMINO ACID GENERATOR AND POLYSILOXANE COMPOSITION CONTAINING THE SAME
  申请人：Kato Taku

  公开号：US20110073977A1

  公开（公告）日：2011-03-31

  There is provided an amino acid generator comprising a protecting group for an amino group that is eliminated to generate an amino acid, and a coating film forming composition using the amino acid generator and a polysiloxane composition containing the amino acid generator. A coating film forming composition comprising: a component (A): an amino acid generator comprising a protecting group that is eliminated to generate an amino acid, which is a compound of Formula (1): D-A (1) where D is a protecting group for an amino group, and A is an organic group remaining after subtracting hydrogen atoms from an amino group of an amino acid; a component (B): a hydrolyzable silane, a hydrolysis product thereof, a hydrolysis-condensation product thereof, or a mixture thereof; and a component (C): a solvent.
• US9173946B2
  申请人：——

  公开号：US9173946B2

  公开（公告）日：2015-11-03