2-Methyl-5-(p-hydroxyphenyl)furan | 93202-31-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-Methyl-5-(p-hydroxyphenyl)furan
• 英文别名: 4-(5-methylfuran-2-yl)phenol
• CAS: 93202-31-4
• 化学式: C₁₁H₁₀O₂
• 分子量: 174.199
• InChiKey: UOXBXKKHDDIQIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-甲氧基苯基)-5-甲基呋喃 在 氢氧化钾 作用下， 以 二乙二醇 为溶剂， 反应 10.0h， 以55%的产率得到2-Methyl-5-(p-hydroxyphenyl)furan
  参考文献：
  名称：

  Antimicrobial activity of 2-arylfuran derivatives and their structural analogs

  摘要：

  DOI：

  10.1007/bf00776796

文献信息

• Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
  申请人：Gillespie Paul

  公开号：US20060122256A1

  公开（公告）日：2006-06-08

  The present invention relates to compounds of formula (I) wherein Ar, Ar 2 , R 2 , R 3 , R 4 , m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.

  本发明涉及以下式(I)的化合物，其中Ar、Ar2、R2、R3、R4、m、p和s如描述和索赔中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与糖原合成酶激活相关的疾病，如糖尿病。
• BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS
  申请人：Gillespie Paul

  公开号：US20090156635A1

  公开（公告）日：2009-06-18

  The present invention relates to compounds of formula (I) wherein Ar, Ar 2 , R 2 , R 3 , R 4 , m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.

  本发明涉及式(I)化合物，其中Ar，Ar2，R2，R3，R4，m，p和s如描述和权利要求中所定义，以及其药学上可接受的盐。该化合物可用于治疗和/或预防与糖原合成酶酶活化有关的疾病，例如糖尿病。
• GLUTARIMIDE DERIVATIVES, USE THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS FOR PRODUCING GLUTARIMIDE DERIVATIVES
  申请人：Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"

  公开号：EP2985282A1

  公开（公告）日：2016-02-17

  The present invention relates to novel biologically active glutarimide derivatives of general formula I or pharmaceutically acceptable salts thereof, their use as an agent for the treatment of upper respiratory tract diseases, pharmaceutical compositions comprising the glutarimide derivatives of general formula I, methods for preparing the glutarimide derivatives of general formula I by heating a dicarboxylic acid monoamide of general formula II with a dehydrating agent.

  本发明涉及通式Ⅰ的新型生物活性戊二酰亚胺衍生物或其药学上可接受的盐、它们作为治疗上呼吸道疾病的制剂的用途、包含通式Ⅰ的戊二酰亚胺衍生物的药物组合物、通过用脱水剂加热通式Ⅱ的二羧酸单酰胺来制备通式Ⅰ的戊二酰亚胺衍生物的方法。
• OLEJNIK, A. F.;VOZYAKOVA, T. I.;FILITIS, L. N.;OKINSHEVICH, O. V.;PERSHIN+, XIM.-FARMATS. ZH., 1984, 18, N 6, 697-699
  作者：OLEJNIK, A. F.、VOZYAKOVA, T. I.、FILITIS, L. N.、OKINSHEVICH, O. V.、PERSHIN+

  DOI：——

  日期：——
• US7524870B2
  申请人：——

  公开号：US7524870B2

  公开（公告）日：2009-04-28