5-[2-(4-fluorophenyl)-1-oxo-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]isoquinolin-3-yl]pentanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-[2-(4-fluorophenyl)-1-oxo-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]isoquinolin-3-yl]pentanoic acid
• 化学式: C₃₁H₂₉FN₂O₄
• 分子量: 512.6
• InChiKey: NQNJIZQEJBHWNF-MUUNZHRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED ISOQUINOLINES AS CRTH2 RECEPTOR MODULATORS
  申请人：HUANG Xianhai

  公开号：US20150353498A1

  公开（公告）日：2015-12-10

  The invention provides certain substituted isoquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters. The invention also provides pharmaceutical compositions comprising for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

  本发明提供了公式（I）的某些取代异喹啉，以及其药学上可接受的盐和酯。本发明还提供了用于治疗与CRTH2功能不受控制或不适当刺激相关的疾病或病况的药物组合物。
• US9290454B2
  申请人：——

  公开号：US9290454B2

  公开（公告）日：2016-03-22
• [EN] SUBSTITUTED ISOQUINOLINES AS CRTH2 RECEPTOR MODULATORS<br/>[FR] ISOQUINOLINES SUBSTITUÉES UTILES COMME MODULATEURS DU RÉCEPTEUR CRTH2
  申请人：MERCK SHARP & DOHME

  公开号：WO2014055311A1

  公开（公告）日：2014-04-10

  The invention provides certain substituted isoquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.