3-Chloro-2-isopropoxy-1,4-naphthoquinone | 67746-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-Chloro-2-isopropoxy-1,4-naphthoquinone
• 英文别名: 2-chloro-3-isopropoxynaphthalene-1,4-dione；1,4-Naphthalenedione, 2-chloro-3-(1-methylethoxy)-；2-chloro-3-propan-2-yloxynaphthalene-1,4-dione
• CAS: 67746-66-1
• 化学式: C₁₃H₁₁ClO₃
• 分子量: 250.682
• InChiKey: QKRFTDNUEHPOJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Chloro-2-isopropoxy-1,4-naphthoquinone 以 苯 为溶剂， 生成
  参考文献：
  名称：

  Depew, M. Catherine; Adeleke, B. B.; Rutter, Allison, Canadian Journal of Chemistry, 1985, vol. 63, p. 2281 - 2284

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二氯-1,4-萘醌 生成 3-Chloro-2-isopropoxy-1,4-naphthoquinone
  参考文献：
  名称：

  CLARK, N. G., PESTIC. SCI., 1984, 15, N 3, 235-240

  摘要：

  DOI：

文献信息

• [EN] NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF<br/>[FR] NAPHTOQUINONES, PROMÉDICAMENTS, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV TEXAS

  公开号：WO2017106624A1

  公开（公告）日：2017-06-22

  Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

  提供在本说明书中的萘醌化合物，例如具有式(I)中的氢键供体基团的那些：其中：R1、R2、R3、R4、R5和n如本文所述定义。此外，还提供了本化合物的药物组合物以及使用这些化合物进行治疗的方法，包括它们在癌症治疗中的应用。
• A method of forming an image, and an imaging element for inhibiting image formation with cobalt (III) complexes
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0003263A1

  公开（公告）日：1979-08-08

  An imaging element contains an energy-activatable image precursor composition comprising a cobalt III complex having releasable ligands which react with an image forming material to form a visible image. The element also contains a photoinhibitor which, on activating exposure, inhibits the release of ligands from the cobalt III complex or inhibits their image forming action. Images may be formed by imagewise activating the photoinhibitor, preferably with radiation longer than 300 nm, and thereafter activating the image precursor composition, for instance by heating. Images of a different sense may be formed by varying the exposure and activation treatments of the element.

  一种成像元件包含一种能量可激活的成像前体组合物，该组合物由钴 III 复合物组成，该钴 III 复合物具有可释放的配体，这些配体与成像材料反应形成可见图像。 该元件还包含一种光抑制剂，该光抑制剂在激活曝光时可抑制配体从钴 III 复合物中释放或抑制其成像作用。 可以通过成像激活光抑制剂（最好使用长于 300 纳米的辐射），然后激活成像前体组合物（例如通过加热）来形成图像。 可以通过改变元件的曝光和激活处理来形成不同意义的图像。
• Phthalaldehyde adduct and image-forming compositions incorporating the same
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0067714A2

  公开（公告）日：1982-12-22

  Novel adducts of phthalaldehyde are disclosed, as well as imaging compositions incorporating them. The adducts are phthalans or isoindolines having the generic formula: wherein Z1 represents the non-metallic atoms necessary to complete a heterocyclic ring system having from 9 to 13 nuclear atoms in from 2 to 3 fused rings; Q represents -O-, >NSO2R2, or -S-; Y represents -OH when Q is or >NSO2R2 and Y is -OR5, -CHR3R4, NR6R7, or -S03M when 0 is -O- or -S-; R1 represents pentafluorophenyl, -CnXH3-n or R2 represents a substituted or unsubstituted alkyl or aralkyl group having from 1 to 11 carbon atoms or a substituted or unsubstituted aryl or alkaryl having from 6 to 11 carbon atoms; R3 and R4 each independently represents a hydrogen atom, a -SO2CH3, -N02, or alkyl group having from 1 to 5 carbon atoms; R5 represents an alkyl group having from 1 to 5 carbon atoms or a group of the structural formula: R6 and R7 each independently represents a hydrogen atom, an -SO2R2 group, or taken together, the atoms necessary to complete a ring having one of the structural formulas: and R13 is an alkyl group having from 1 to 5 carbon atoms; M is a metal; X is a halogen; and n is 1, 2 or 3.

  本文公开了邻苯二甲醛的新型加合物以及含有这些加合物的成像组合物。这些加合物是具有通式的邻苯二甲酸酯或异吲哚啉： 其中 Z1 代表完成一个杂环系统所需的非金属原子，该杂环系统在 2 至 3 个融合环中具有 9 至 13 个核原子； Q 代表-O-、 >NSO2R2 或 -S-； 当 Q 为-OH 时，Y 代表-OH 或 >NSO2R2 当 Q 为或 >NSO2R2 时，Y 代表-OH 当 0 为-O-或-S-时，NR6R7 或-S03M； R1 代表五氟苯基，-CnXH3-n 或 R2 代表具有 1 至 11 个碳原子的取代或未取代的烷基或芳烷基，或具有 6 至 11 个碳原子的取代或未取代的芳基或芳烷基； R3 和 R4 各自独立地代表氢原子、-SO2CH3、-N02 或具有 1 至 5 个碳原子的烷基； R5 代表具有 1 至 5 个碳原子的烷基或结构式如下的基团： R6 和 R7 各自独立地代表一个氢原子、一个 -SO2R2 基团，或共同代表完成具有以下结构式之一的环所需的原子： 和 R13 是具有 1 至 5 个碳原子的烷基； M 是金属 X 是卤素 n 是 1、2 或 3。
• Imaging film and film-forming composition, method for recording electromagnetic radiation, quinone compounds and method of synthesizing quinone compounds
  申请人：ENERGY CONVERSION DEVICES, INC.

  公开号：EP0098020A2

  公开（公告）日：1984-01-11

  Imaging films and film-forming compositions are provided which include a reducible tellurium compound, a reductant precursor, a source of labile hydrogen incorporated in a matrix. The reductant precursors are of the formulae or where Y1 is alkoxy, Y2 is chloro or alkoxy and Y3 is hydrogen, chloro or alkoxy. Methods are provided for synthesizing the reductant precursors.

  提供了成像薄膜和成膜组合物，其中包括一种可还原的碲化合物、一种还原剂前体、一种结合在基质中的易变氢源。 还原剂前体的式子为 Y1 是烷氧基，Y2 是氯或烷氧基，Y3 是氢、氯或烷氧基。 提供了合成还原剂前体的方法。
• Quinone synthesis
  申请人：ENERGY CONVERSION DEVICES, INC.

  公开号：EP0178904A2

  公开（公告）日：1986-04-23

  A process for producing a quinone of the formula wherein n is zero, 1 or 2; Y' is alkoxy; Y2 is H, C1, Br or alkoxy; and R' and R" are independently selected from H, alkyl and phenyl, which comprises the steps of: (a) reacting a tetrabromide of the formula with potassium iodide; (b) reacting the product of step (a) with a 2-alkoxy-1,4-benzoquinone, to give the desired quinone when Y2 is H; (c) if desired, reacting the quinone in which Y2 is H with C12 or Br2, to give the desired quinone in which Y2 is C1 or Br; and (d) if desired, reacting the quinone in which Y2 is C1 or Br with a lithium, sodium or potassium alkoxide, to give the desired quinone in which Y2 is alkoxy.

  一种生产式醌的工艺 其中n为零、1或2；Y'为烷氧基；Y2为H、C1、Br或烷氧基；R'和R "独立地选自H、烷基和苯基，该工艺包括以下步骤 (a) 式中的四溴化物与碘化钾反应 与碘化钾反应 (b) 当 Y2 为 H 时，将步骤（a）的产物与 2-烷氧基-1,4-苯醌反应，得到所需的醌； (c) 如果需要，将 Y2 为 H 的醌与 C12 或 Br2 反应，得到 Y2 为 C1 或 Br 的所需醌；以及 (d) 如果需要，将 Y2 为 C1 或 Br 的醌与锂、钠或钾氧化碱反应，得到 Y2 为烷氧基的所需醌。