2-(Dipropylamino)-1,2,3,4-tetrahydronaphthalen-1-ol;hydrobromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-(Dipropylamino)-1,2,3,4-tetrahydronaphthalen-1-ol;hydrobromide
• 英文别名: 2-(dipropylamino)-1,2,3,4-tetrahydronaphthalen-1-ol;hydrobromide
• 化学式: C16H26BrNO
• 分子量: 328.29
• InChiKey: PTGCONINMJWOKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON DISEASE BY THE SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES
  申请人：Nlife Therapeutics S.L.

  公开号：EP2911695A1

  公开（公告）日：2015-09-02
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON DISEASE BY THE SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE LA MALADIE DE PARKINSON PAR ADMINISTRATION SÉLECTIVE DE MOLÉCULES D'OLIGONUCLÉOTIDES À DES TYPES SPÉCIFIQUES DE NEURONES
  申请人：NLIFE THERAPEUTICS S L

  公开号：WO2014064257A1

  公开（公告）日：2014-05-01

  The invention provides a conjugate comprising(i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (DAT), serotonine transporter (SERT) or a norepinephrine transporter (NET) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is α-synuclein or the mRNA encoding α-synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes.