[(2R)-1-hydroperoxy-3-pentoxypropan-2-yl] 2-(trimethylazaniumyl)ethyl phosphate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [(2R)-1-hydroperoxy-3-pentoxypropan-2-yl] 2-(trimethylazaniumyl)ethyl phosphate
• 化学式: C13H30NO7P
• 分子量: 343.35
• InChiKey: PUUKYWNUPASLEP-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Agents for improved delivery of nucleic acids to eukaryotic cells
  申请人：Molecular Transfer Inc.

  公开号：US10138497B2

  公开（公告）日：2018-11-27

  New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.

  本研究提供了可用于将核酸等大分子递送到真核细胞中的新型阳离子脂质。这些脂质可单独使用，也可与其他脂质结合使用，或与其他转染增强试剂结合使用，以制备转染复合物。
• Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells
  申请人：MOLECULAR TRANSFER, INC.

  公开号：US10155780B2

  公开（公告）日：2018-12-18

  New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. The present invention is in the field of molecular biology, and more particularly in the field of transfection, which utilizes new compounds and methods for the introduction of nucleic acids into eukaryotic cells.

  本研究提供了可用于将核酸等大分子递送到真核细胞中的新型阳离子脂质。这些脂质可单独使用，也可与其它脂质结合使用，和/或与其它转染增强试剂结合使用，以制备转染复合物。本发明属于分子生物学领域，尤其是转染领域，它利用新的化合物和方法将核酸导入真核细胞。
• Transfection complexes and methods of using the same
  申请人：MOLECULAR TRANSFER, INC.

  公开号：US11085056B2

  公开（公告）日：2021-08-10

  Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.

  本文公开的转染复合物包含至少一种细胞表面配体；至少一种辅助脂质成分；以及一种转染增强剂。还公开了包含所公开的转染复合物和药学上可接受的载体的药物组合物。此外，还公开了转染细胞的方法，该方法包括以下步骤：获得所公开的转染复合物；细胞与转染复合物接触。
• AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
  申请人：Molecular Transfer, Inc.

  公开号：EP2696678B1

  公开（公告）日：2019-11-20
• POLYCATIONIC METHYL PHOSPHOLIPIDS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS
  申请人：Molecular Transfer, Inc.

  公开号：EP2912045A2

  公开（公告）日：2015-09-02