1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
• 化学式: C54H66N6O12S2
• 分子量: 1055.3
• InChiKey: KLCBCHRIULNYTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.04
• 重原子数：
  74
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  261
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL
  申请人：Pharnext

  公开号：EP2914252A1

  公开（公告）日：2015-09-09
• COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES
  申请人：Pharnext

  公开号：EP3137065A2

  公开（公告）日：2017-03-08
• [EN] COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL<br/>[FR] COMPOSITIONS, PROCÉDÉS ET UTILISATIONS POUR LE TRAITEMENT DU DIABÈTE ET D'ÉTATS ASSOCIÉS EN RÉGULANT LE NIVEAU DE GLYCÉMIE
  申请人：PHARNEXT

  公开号：WO2014068007A1

  公开（公告）日：2014-05-08

  The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.
• [EN] COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL<br/>[FR] COMPOSITIONS, PROCÉDÉS ET UTILISATIONS POUR LE TRAITEMENTS DE DIABÈTE ET D'ÉTATS ASSOCIÉS EN RÉGULANT LE NIVEAU DE GLYCÉMIE
  申请人：PHARNEXT

  公开号：WO2015063140A1

  公开（公告）日：2015-05-07

  The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.
• [EN] COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES<br/>[FR] COMPOSITIONS, PROCÉDÉS ET UTILISATIONS POUR LE TRAITEMENT DE NEUROPATHIES DIABÉTIQUES
  申请人：PHARNEXT

  公开号：WO2015165948A2

  公开（公告）日：2015-11-05

  The present invention relates to compositions and methods for the treatment of diabetic neuropathies. More particularly, this invention relates to compositions and methods for promoting nerve regeneration in a subject suffering from, or at risk of suffering from a diabetic neuropathy, and for protecting nervous system cells against the stresses resulting from the perturbation of glucose homeostasis. More specifically, the present invention relates to novel single or combination therapies for diabetic neuropathies, comprising diabetic peripheral neuropathy, diabetic proximal neuropathy, diabetic autonomic neuropathy and diabetic focal neuropathy, based on restoring dorsal root ganglion neurons and other nerves integrity.