1-Pentylpyrrolo[3,2-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 1-Pentylpyrrolo[3,2-d]pyrimidine
• 英文别名: 1-pentylpyrrolo[3,2-d]pyrimidine
• 化学式: C₁₁H₁₅N₃
• 分子量: 189.26
• InChiKey: NCPQTTUXQCCVIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] IDENTIFICATION, ASSESSMENT AND THERAPY OF ESSENTIAL THROMBOCYTHEMIA WITH RESISTANCE TO JAK2 INHIBITORS<br/>[FR] IDENTIFICATION, ÉVALUATION ET TRAITEMENT DE LA THROMBOCYTÉMIE ESSENTIELLE ASSOCIÉE À UNE RÉSISTANCE AUX INHIBITEURS DE JAK2
  申请人：ROUSSY INST GUSTAVE

  公开号：WO2014068072A1

  公开（公告）日：2014-05-08

  The inventors herein disclose mutations that naturally occur in the JAK2 gene sequence of human patients suffering from essential thrombocythemia and that confer resistance to commonly used JAK2 inhibitors and/or Hsp90 inhibitors. The present invention therefore relates to methods, compositions and kits aiming to detect the presence of these mutations so as to predict and try to overcome the patient resistance to treatment involving JAK2 inhibitors and/or Hsp90 inhibitors. Moreover, the invention describes a model to test new drugs and JAK2 inhibitors.