3-(4-chloro-2-fluoro-N-[7-methoxy-6-(1-prop-2-enoylpiperidin-4-yl)oxyquinazolin-4-yl]-3-methylanilino)-1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]propan-1-one

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(4-chloro-2-fluoro-N-[7-methoxy-6-(1-prop-2-enoylpiperidin-4-yl)oxyquinazolin-4-yl]-3-methylanilino)-1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
• 化学式: C₄₇H₄₅Cl₃F₂N₈O₆
• 分子量: 962.3
• InChiKey: SMBJORNHZNOXND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  66
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  14

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING AMIDE DERIVATIVE INHIBITING THE GROWTH OF CANCER CELLS AND NON-METALLIC SALT LUBRICANT
  申请人：Kim Yong Il

  公开号：US20140112962A1

  公开（公告）日：2014-04-24

  Disclosed is a pharmaceutical composition comprising an amide derivative or a pharmaceutically acceptable salt thereof and a non-metallic salt lubricant, which can be used as an effective cancer cell-growth inhibitor owing to its enhanced storage stability with no quality changes over time.
• US9731022B2
  申请人：——

  公开号：US9731022B2

  公开（公告）日：2017-08-15