8-chloro-6,7-dihydroxy-3-methyl-2H-phthalazine-1,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-chloro-6,7-dihydroxy-3-methyl-2H-phthalazine-1,4-dione
• 化学式: C₉H₇ClN₂O₄
• 分子量: 242.61
• InChiKey: BALPSJAMQVGZIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] 2 SUBSTITUTED CEPHEM COMPOUNDS<br/>[FR] COMPOSÉS DE CÉPHEM SUBSTITUÉS EN POSITION 2
  申请人：GLAXO GROUP LTD

  公开号：WO2014068388A1

  公开（公告）日：2014-05-08

  The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

  本发明的化学式（I）的化合物与2-取代头孢菌素类化合物相关，具有广泛的抗微生物谱，特别对产β-内酰胺酶的革兰氏阴性细菌表现出强效的抗微生物活性，并且包含这些化合物的药物组合物。
• CEPHEM COMPOUND
  申请人：SHIONOGI & CO., LTD.

  公开号：US20150344502A1

  公开（公告）日：2015-12-03

  A compound of the formula: wherein, W is —CH2 − etc.; U is —S − etc.; R 1 is substituted or unsubstituted carbocyclyl etc.; R 2A and R 2B is a) or b) described in the specification; R 3 is a hydrogen atom etc.; R 11 is carboxylate anion (—COO − ) etc.; L is substituted or unsubstituted lower alkylene etc., E is a substituted or unsubstituted divalent group containing quaternary ammonium ion; G is a single bond etc.; D is —C(═O)—C(═O)—NR 6 — etc.; R 10 1) to 3) described in specification; or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

  公式为：其中，W为—CH2−等；U为—S−等；R1为取代或未取代的碳环等；R2A和R2B为规范中描述的a)或b)；R3为氢原子等；R11为羧酸根离子(—COO−)等；L为取代或未取代的较低烷基等；E为含季铵离子的取代或未取代的双价基团；G为单键等；D为—C(═O)—C(═O)—NR6—等；R10为规范中描述的1)至3)；或者是7-侧链环上存在氨基时的氨基保护化合物，或其药用可接受盐。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• 2 SUBSTITUTED CEPHEM COMPOUNDS
  申请人：Glaxo Group Limited

  公开号：US20170281532A1

  公开（公告）日：2017-10-05

  The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.