(2Z)-2-[(Z)-but-2-enylidene]-3-[(Z)-3-iminoprop-1-enyl]-4-methylcyclopent-3-en-1-imine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2Z)-2-[(Z)-but-2-enylidene]-3-[(Z)-3-iminoprop-1-enyl]-4-methylcyclopent-3-en-1-imine
• 化学式: C₁₃H₁₆N₂
• 分子量: 200.28
• InChiKey: IOGOVHKIAMAACM-QIDCWSEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  47.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Methods for Preparing Polymeric Reagents
  申请人：Nektar Therapeutics

  公开号：US20140107349A1

  公开（公告）日：2014-04-17

  The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.

  本发明提供了制备聚合试剂的方法，其中该方法包括(a)提供一种带有羟基、第一氨基和第二氨基的芳香基团；(b)将功能性试剂与羟基反应，得到带有能够与活性试剂的氨基基团反应并生成可水解的氨基甲酸酯的官能基的羟基基团；(c)将带有反应基团的多种聚(烷氧基乙烯醇)水溶性聚合物与第一氨基和第二氨基反应，得到(i)通过间隔基团带有第一氨基的水溶性聚合物，以及(ii)通过间隔基团带有第二氨基的第二种水溶性聚合物。
• METHODS FOR PREPARING POLYMERIC REAGENTS
  申请人：Nektar Therapeutics

  公开号：US20160022830A1

  公开（公告）日：2016-01-28

  The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.

  本发明提供了制备高分子试剂的方法，其中该方法包括：（a）提供一种带有羟基、第一氨基和第二氨基的芳香基团；（b）将一个官能团试剂与羟基反应，结果得到带有官能团的羟基，该官能团能够与活性剂的氨基反应，并产生可水解的碳酸酯；（c）将多种聚（烷基乙二醇）水溶性高分子带有反应基团与第一氨基和第二氨基反应，结果得到（i）通过间隔基团与第一氨基结合的水溶性高分子，和（ii）通过间隔基团与第二氨基结合的第二种水溶性高分子。
• COMPOSITION COMPRISING A POLYMERIC REAGENT
  申请人：Nektar Therapeutics

  公开号：US20160324973A1

  公开（公告）日：2016-11-10

  The present invention provides among other things a composition of a polymeric reagent and an antioxidant, such as butylated hydroxyl toluene.
• US8703115B2
  申请人：——

  公开号：US8703115B2

  公开（公告）日：2014-04-22
• US8911718B2
  申请人：——

  公开号：US8911718B2

  公开（公告）日：2014-12-16