naphthalene-1,2-dicarboxamide | 91973-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphthalene-1,2-dicarboxamide
• 英文别名: Naphthalin-1,2-dicarbamid；Naphthalenedicarboxamide
• CAS: 91973-65-8
• 化学式: C₁₂H₁₀N₂O₂
• 分子量: 214.224
• InChiKey: JXRWDHUZHAWOLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  naphthalene-1,2-dicarboxamide 生成 1H-benzo[e]isoindole-1,3(2H)-dione
  参考文献：
  名称：

  Cleve, Chemische Berichte, 1892, vol. 25, p. 2486

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-萘二甲腈 在 sodium hydroxide 作用下， 生成 naphthalene-1,2-dicarboxamide
  参考文献：
  名称：

  Cleve, Chemische Berichte, 1892, vol. 25, p. 2486

  摘要：

  DOI：

文献信息

• Pyrido[3,2-h]quinazolines and/or 5,6-dihydro derivatives thereof, a method for the production thereof and doped organic semiconductor material containing these
  申请人：Saalbeck Josef

  公开号：US20080227979A1

  公开（公告）日：2008-09-18

  The present invention relates to pyrido[3,2-h]quinazolines and/or 5,6-dihydro derivatives thereof, methods for their production and doped organic semiconductor material which use such quinazolines.

  本发明涉及吡啶并[3,2-h]喹唑啉和/或其5,6-二氢衍生物，其生产方法以及使用此类喹唑啉的掺杂有机半导体材料。
• DRUG FOR TREATING TUMOR DISEASES AND HAVING ANTIBACTERIAL ANTIVIRUS ANTI-INFLAMMATORY EFFECTS
  申请人：Shi Jianyou

  公开号：US20210094910A1

  公开（公告）日：2021-04-01

  The present disclosure describes an anti-cancer drug for treating tumor diseases and providing antibacterial, antivirus, and anti-inflammatory effects. The drug contains a naphthalene dicarboxamide compound with a structural formula as shown in Formula I or a biologically acceptable salt or ester form of the compound with the formula I as an active ingredient. The drug is able to help inhibit the growth of tumor cells and possesses certain antibacterial, antivirus, and anti-inflammatory effects.

  本公开说明书描述了一种用于治疗肿瘤疾病并提供抗菌、抗病毒和抗炎作用的抗癌药物。该药物包含一种萘二甲酰胺化合物，其结构式如公式I所示，或者该化合物的生物可接受的盐或酯形式作为活性成分。该药物能够帮助抑制肿瘤细胞的生长，并具有一定的抗菌、抗病毒和抗炎作用。
• [EN] N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS<br/>[FR] COMPOSÉS N-HYDROXY-NAPHTALÈNE DICARBOXAMIDE ET N-HYDROXY-BIPHÉNYL-DICARBOXAMIDE COMME INHIBITEURS DE L'HISTONE DÉSACÉTYLASE
  申请人：MERCK & CO INC

  公开号：WO2009045385A1

  公开（公告）日：2009-04-09

  The present invention relates to a novel class of N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide derivatives. The N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds can be used to treat cancer. The N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide derivatives in vivo.

  本发明涉及一类新型的N-羟基-萘二甲酰胺和N-羟基联苯二甲酰胺衍生物。N-羟基-萘二甲酰胺和N-羟基联苯二甲酰胺化合物可用于治疗癌症。N-羟基-萘二甲酰胺和N-羟基联苯二甲酰胺化合物还可以抑制组蛋白去乙酰化酶，并适用于选择性诱导末端分化、阻止肿瘤细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有肿瘤细胞增殖特征的患者。本发明的化合物也可用于预防和治疗TRX介导的疾病，如自身免疫、过敏和炎症性疾病，以及中枢神经系统（CNS）疾病的预防和/或治疗，如神经退行性疾病。本发明还提供包含N-羟基-萘二甲酰胺和N-羟基联苯二甲酰胺衍生物的制药组合物和这些制药组合物的安全用量方案，易于遵循，并在体内产生治疗有效量的N-羟基-萘二甲酰胺和N-羟基联苯二甲酰胺衍生物。
• PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS
  申请人：Allen David George

  公开号：US20090326003A1

  公开（公告）日：2009-12-31

  The present invention provides a compound of formula (I) or a salt thereof (in particular, a pharmaceutically acceptable salt thereof): The invention also provides the use of the compounds or salts as inhibitors of phosphodiesterase type IV (PDE4) for the treatment or prophylaxis of inflammatory or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, atopic dermatitis or psoriasis, e.g. in a mammal such as a human.

  本发明提供了式（I）的化合物或其盐（特别是其药学上可接受的盐）：本发明还提供了将该化合物或盐用作磷酸二酯酶IV（PDE4）的抑制剂，用于治疗或预防炎症或过敏性疾病，如慢性阻塞性肺疾病（COPD），哮喘，鼻炎，特应性皮炎或银屑病，例如在哺乳动物，如人类中。
• Pyrido[3,2-h]quinazolines and/or 5,6-dihydro Derivatives Thereof, a Method for the Production Thereof and Doped Organic Semiconductor Material Containing These
  申请人：Salbeck Josef

  公开号：US20110046374A1

  公开（公告）日：2011-02-24

  The present invention relates to pyrido[3,2-h]quinazolines and/or 5,6-dihydro derivatives thereof, methods for their production and doped organic semiconductor material which use such quinazolines.

  本发明涉及吡啶并[3,2-h]喹唑啉和/或其5,6-二氢衍生物，其生产方法以及使用这种喹唑啉的掺杂有机半导体材料。