2-Azanonylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Azanonylamine
• 英文别名: N'-heptylmethanediamine
• 化学式: C₈H₂₀N₂
• 分子量: 144.26
• InChiKey: KIQJGHREEIWLFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR<br/>[FR] LIGANDS SÉLECTIFS DU RÉCEPTEUR D'ANDROSTANE CONSTITUTIF HUMAIN
  申请人：USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I

  公开号：WO2020221380A1

  公开（公告）日：2020-11-05

  The present invention provides a structurally novel class of heterocyclic compounds of general formula I wherein L1 is heteroaryl and L2 is heteroaryl or aryl. The novel compounds are useful in a method of prevention or treatment of a condition which is mediated by the action, or by loss of action, of Constitutive androstane receptor (CAR) receptor or its endogenous ligands. The present invention thus provides the novel compounds for medicinal use, as well as pharmaceutical composition containing said compounds. (I)

  本发明提供了一类结构新颖的杂环化合物，其通用公式为I，其中L1是杂芳基，L2是杂芳基或芳基。这些新颖化合物在预防或治疗由构成雄烷受体（CAR）受体或其内源性配体的作用或作用丧失介导的疾病的方法中是有用的。因此，本发明提供了用于药用的新颖化合物，以及含有所述化合物的药物组合物。(I)
• RESIN COMPOSITION AND MULTILAYERED STRUCTURE USING SAME
  申请人：Mitsubishi Chemical Corporation

  公开号：EP3540008A1

  公开（公告）日：2019-09-18

  Provided is a resin composition comprising an ethylene-vinyl alcohol copolymer (A), a hydrate-forming metal salt (B), and a polyamide-based resin (C) that inhibits elution of a resin composition layer during hot water sterilization treatment of a multilayered structure including the resin composition layer, while suppressing odor during melt molding of the resin composition. An aromatic polyamide (C1) and an aliphatic polyamide (C2) are used for the polyamide-based resin (C) at a proportion of (C1)/(C2) = 55/45 -99/1.

  本发明提供了一种由乙烯-乙烯醇共聚物（A）、水合金属盐（B）和聚酰胺基树脂（C）组成的树脂组合物，该树脂组合物在对包括树脂组合物层的多层结构进行热水灭菌处理时可抑制树脂组合物层的洗脱，同时在树脂组合物熔融成型时可抑制气味。聚酰胺基树脂 (C) 使用芳香族聚酰胺 (C1) 和脂肪族聚酰胺 (C2)，比例为 (C1)/(C2) = 55/45 -99/1。
• Resin composition and multilayered structure using same
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US11401407B2

  公开（公告）日：2022-08-02

  Provided is a resin composition comprising an ethylene-vinyl alcohol copolymer (A), a hydrate-forming metal salt (B), and a polyamide-based resin (C) that inhibits elution of a resin composition layer during hot water sterilization treatment of a multilayered structure including the resin composition layer, while suppressing odor during melt molding of the resin composition. An aromatic polyamide (C1) and an aliphatic polyamide (C2) are used for the polyamide-based resin (C) at a proportion of (C1)/(C2)=55/45-99/1.

  本发明提供了一种由乙烯-乙烯醇共聚物（A）、水合金属盐（B）和聚酰胺基树脂（C）组成的树脂组合物，该树脂组合物在对包括树脂组合物层的多层结构进行热水灭菌处理时可抑制树脂组合物层的洗脱，同时在树脂组合物熔融成型时可抑制气味。聚酰胺基树脂 (C) 使用芳香族聚酰胺 (C1) 和脂肪族聚酰胺 (C2)，比例为 (C1)/(C2)=55/45-99/1 。
• OLIGONUCLEOTIDES FOR TREATING EXPANDED REPEAT DISEASES
  申请人：Sarepta Therapeutics, Inc.

  公开号：EP2785729B1

  公开（公告）日：2020-11-04
• METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY
  申请人：The John Hopkins University

  公开号：EP2782583B1

  公开（公告）日：2019-09-25