1-(7-methyl-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)propan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 1-(7-methyl-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)propan-2-one
• 化学式: C₁₃H₁₇NOS
• 分子量: 235.35
• InChiKey: CLZHLXUMBKBRHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ADMINISTERING INHIBITORS OF TGFBETA SIGNALING IN COMBINATION WITH BENZOTHIAZEPINE DERIVATIVES TO IMPROVE MUSCLE FUNCTION IN CANCER PATIENTS
  申请人：of Columbia University in the City of New York The Trustees

  公开号：US20140128349A1

  公开（公告）日：2014-05-08

  Methods and compositions useful for the treatment and/or prevention of muscle weakness in cancer patients. In certain embodiments, the methods of the present invention include administering to a cancer patient a therapeutically or prophylactically effective amount of one or more inhibitors of TGFbeta signaling in combination with one or more benzothiazepine derivatives.