(2R)-N,N-dimethyl-1-nonan-2-yloxy-1-[(9Z,12Z)-octadeca-9,12-dienoxy]propan-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2R)-N,N-dimethyl-1-nonan-2-yloxy-1-[(9Z,12Z)-octadeca-9,12-dienoxy]propan-2-amine
• 化学式: C₃₂H₆₃NO₂
• 分子量: 493.8
• InChiKey: XOKLVOMLIIIOKF-VUMUZXRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  35
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HNF4A saRNA compositions and methods of use
  申请人：MiNA THERAPEUTICS LIMITED

  公开号：US11162099B2

  公开（公告）日：2021-11-02

  The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

  本发明涉及靶向 HNF4a 转录本的 saRNA 和包含所述 saRNA 的治疗组合物。本发明还提供了使用治疗组合物的方法。
• MODIFIED POLYNUCLEOTIDES ENCODING SIAH E3 UBIQUITIN PROTEIN LIGASE 1
  申请人：Bancel Stephane

  公开号：US20140141068A1

  公开（公告）日：2014-05-22

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
• COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150005372A1

  公开（公告）日：2015-01-01

  The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160152678A1

  公开（公告）日：2016-06-02

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
• BROAD SPECTRUM INFLUENZA VIRUS VACCINE
  申请人：Moderna TX, Inc.

  公开号：US20180311336A1

  公开（公告）日：2018-11-01

  The disclosure relates to influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.