N-ethenyl-N-(methylideneamino)propan-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethenyl-N-(methylideneamino)propan-2-amine
• 化学式: C₆H₁₂N₂
• 分子量: 112.17
• InChiKey: QKNDTQCSEGVKNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS<br/>[FR] COMPOSÉS MACROCYCLIQUES POUR L'INHIBITION D'INHIBITEURS DE L'APOPTOSE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014074658A1

  公开（公告）日：2014-05-15

  There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

  这里公开了调节凋亡抑制剂（IAPs）活性的化合物，包含所述化合物的药物组合物以及使用本发明的化合物治疗增殖性疾病和凋亡失调疾病的方法，例如癌症。
• [EN] NOVEL QUINOLINE DERIVATIVE INHIBITOR<br/>[FR] NOUVEL INHIBITEUR DE DÉRIVÉ DE QUINOLÉINE<br/>[ZH] 一种新型的喹啉衍生物抑制剂
  申请人：NANJING TRANSTHERA BIOSCIENCES CO LTD

  公开号：WO2020038460A1

  公开（公告）日：2020-02-27

  本发明提供一种新型的喹啉衍生物抑制剂，其具有下述通式(I)所示的结构，本发明的化合物可选择性抑制酪氨酸激酶TAM家族/和CSF1R激酶，可用于TAM家族激酶/和CSF1R激酶受体和/或其配体异常表达所介导的疾病治疗和/或预防，进而，本发明的化合物可以用于治疗和/或预防由NTRK引发的相关疾病，更具体而言，可以用于治疗和/或预防由NTRK突变产生的耐药型的相关疾病。(I) 各基团定义如说明书所示。
• HETEROCYCLIC DERIVATIVE AND USE THEREOF
  申请人：Transthera Sciences (Nanjing), Inc.

  公开号：US20220298146A1

  公开（公告）日：2022-09-22

  Disclosed are a TAM family kinase/and Ron kinase inhibitor compound as shown in general formula (I), a pharmaceutically acceptable salt, an ester, a stereoisomer and a tautomer thereof, a pharmaceutical composition and a pharmaceutical preparation containing same, and the use thereof. The compound can selectively inhibit TAM family tyrosine kinase/and Ron kinase, and can be used for the treatment and/or prevention of diseases mediated by the abnormal expression of a receptor of TAM family kinase/and Ron kinase and/or a ligand thereof. By means of targeted inhibition of the TAM family kinase/and Ron kinase, the compound can reverse the immunosuppressive environment in a tumor microenvironment, inhibit the growth, migration and/or drug resistance performance of tumors, and exert anti-tumor immunological effects and anti-tumor efficacy. The definition of each group in the formula is described in the specification.