3-[4-Aminobutoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[4-Aminobutoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• 英文别名: 3-[4-aminobutoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• 化学式: C₁₃H₂₈N₃O₂P
• 分子量: 289.35
• InChiKey: WOUYOOIAWCONER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
  申请人：RAYMOND Kenneth N.

  公开号：US20120329174A1

  公开（公告）日：2012-12-27

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

  本发明提供了一类新型的大环化合物，以及由金属（例如镧系金属）离子和本发明化合物形成的配合物。优选的配合物在无需二次激活剂的情况下，在水介质中表现出高稳定性和高镧系离子荧光量子产率。优选的化合物在其大环结构中包含羟基异苯酰胺基团，并以出人意料的低非特异性结合多种多肽（如抗体和蛋白质）以及高动力学稳定性为特征。这些特征使它们与已知的开放结构配体有所区别。
• US8173800B2
  申请人：——

  公开号：US8173800B2

  公开（公告）日：2012-05-08
• US8729258B2
  申请人：——

  公开号：US8729258B2

  公开（公告）日：2014-05-20