1-(6-bromo-2H-1,3-benzothiazol-3-yl)propan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 1-(6-bromo-2H-1,3-benzothiazol-3-yl)propan-2-one
• 化学式: C₁₀H₁₀BrNOS
• 分子量: 272.16
• InChiKey: DGCFHVRUCJCXGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA
  申请人：The Johns Hopkins University

  公开号：EP2919788A1

  公开（公告）日：2015-09-23
• METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
  申请人：The Johns Hopkins University

  公开号：EP2968237A1

  公开（公告）日：2016-01-20
• [EN] METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE LA SCHIZOPHRÉNIE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014078568A1

  公开（公告）日：2014-05-22

  The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an antipsychotic or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs, and prodrugs thereof. The methods and the compositions can be used for treating one or more positive and/or negative symptoms, as well as cognitive impairment, associated with schizophrenia or bipolar disorder (in particular, mania).
• [EN] METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR AMÉLIORER LA FONCTION COGNITIVE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014144663A1

  公开（公告）日：2014-09-18

  This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment.