N,N'-(5,5'-((1R,4R)-cyclohexane-1,4-diylbis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-(pyridin-2-yl)acetamide))

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-(5,5'-((1R,4R)-cyclohexane-1,4-diylbis(methylene)bis(1,3,4-thiadiazole-5,2-diyl))bis(2-(pyridin-2-yl)acetamide))
• 英文别名: N,N'-(5,5'-((trans)-cyclohexane-1,4-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-(pyridin-2-yl)acetamide)；2-pyridin-2-yl-N-[5-[[4-[[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]methyl]cyclohexyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide
• 化学式: C₂₆H₂₈N₈O₂S₂
• 分子量: 548.693
• InChiKey: VBIKDQUKQWLKTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  192
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• NOVEL INHIBITORS OF GLUTAMINASE
  申请人：RHIZEN PHARMACEUTICALS SA

  公开号：US20160297761A1

  公开（公告）日：2016-10-13

  The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders involving glutamine
• [EN] NOVEL INHIBITORS OF GLUTAMINASE<br/>[FR] NOUVEAUX INHIBITEURS DE GLUTAMINASE
  申请人：RHIZEN PHARMACEUTICALS SA

  公开号：WO2015101958A2

  公开（公告）日：2015-07-09

  The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders involving glutamine.