1.4-Bis-dimethylamino-cyclohexan | 64945-67-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1.4-Bis-dimethylamino-cyclohexan
• 英文别名: cis-1,4-Cyclohexanediamine, N1,N1,N4,N4-tetramethyl；1-N,1-N,4-N,4-N-tetramethylcyclohexane-1,4-diamine
• CAS: 64945-67-1
• 化学式: C₁₀H₂₂N₂
• 分子量: 170.298
• InChiKey: RNSVQNMGXFXULJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 cyclohexane-1,4-dione dioxime 生成 1.4-Bis-dimethylamino-cyclohexan
  参考文献：
  名称：

  Vejdelek,Z.J. et al., Collection of Czechoslovak Chemical Communications, 1960, vol. 25, p. 245 - 253

  摘要：

  DOI：

文献信息

• ANTIMICROBIAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND USES THEREOF
  申请人：Coady Daniel J.

  公开号：US20120251607A1

  公开（公告）日：2012-10-04

  A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.

  一种物质的组成包括阳离子聚合物，该阳离子聚合物包括聚碳酸酯链片段，所述聚碳酸酯链片段包括一个重复单元，所述重复单元包括一个含季铵胺基团的侧链部分；以及一种非带电聚合物，包括聚酯链段和聚（烷基氧化物）链段；其中i）所述阳离子聚合物和非带电聚合物是两性且生物相容的，ii）所述阳离子聚合物和非带电聚合物在水中通过非共价相互作用形成混合复合物，iii）与单独使用时，所述混合复合物在至少一种革兰氏阴性微生物的抗菌剂测试中比阳离子聚合物和非带电聚合物更有效。
• ANTIMICROBIAL POLYMERS AND METHODS OF MANUFACTURE THEREOF
  申请人：HEDRICK James

  公开号：US20110150977A1

  公开（公告）日：2011-06-23

  Biodegradable cationic block copolymers are disclosed, comprising a hydrophilic block comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a hydrophobic block comprising second repeat units derived from a second cyclic carbonyl monomer by ring-opening polymerization; an optional endcap group; and a chain fragment derived from an initiator for the ring opening polymerization. The cationic block copolymers form aqueous micelle mixtures suitable for antimicrobial applications.

  披露了可生物降解的阳离子嵌段共聚物，包括由第一环状羰基单体通过环开聚合得到的第一重复单元构成的亲水性嵌段，其中超过0%的第一重复单元包含一个侧链基团，该侧链基团包含一个季铵盐基团；包括由第二环状羰基单体通过环开聚合得到的第二重复单元构成的疏水性嵌段；一个可选的端基团；以及由环开聚合引发剂导致的链片段。这些阳离子嵌段共聚物形成适用于抗菌应用的水胶胶束混合物。
• ANTIMICROBIAL HYDROGELS, METHODS OF PREPARATION THEREOF, AND ARTICLES THEREFROM
  申请人：Coady Daniel Joseph

  公开号：US20120231060A1

  公开（公告）日：2012-09-13

  A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P′ covalently linked at respective first end units to a branched first core group C′, b) three or more divalent poly(alkylene oxide) chains P″ covalently linked at respective first end units to a branched second core group C″, the chains P″ comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P′ by divalent linking groups L″, and c) at least one pendant cationic block copolymer chain A′-B′. A′-B′ comprises i) a divalent block A′ comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P′ by a divalent linking group L′, and ii) a monovalent block B′ comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.

  一种共价交联的水凝胶包括a) 三个或更多个二价聚(烷氧基烷氧基)链P′，其在各自的第一端单元上共价连接到分支的第一核心基团C′，b) 三个或更多个二价聚(烷氧基烷氧基)链P″，其在各自的第一端单元上与分支的第二核心基团C″共价连接，链P″包括通过二价连接基团L″与链P′的各自第二端单元之间共价连接到0%至100%的各自第二端单元的第二端单元，以及c) 至少一个挂链阳离子嵌段共聚物链A′-B′。A′-B′包括i) 一个二价块A′，包括一个与链P′中的一个链的第二端单元通过二价连接基团L′共价连接的聚(烷氧基烷氧基)骨架链，以及ii) 一个一价块B′，包括第一个重复单元，该第一个重复单元包括一个骨架碳酸酯基团和一个阳离子侧链基团。
• CATIONIC POLYMERS FOR ANTIMICROBIAL APPLICATIONS AND DELIVERY OF BIOACTIVE MATERIALS
  申请人：Coady Daniel Joseph

  公开号：US20120251608A1

  公开（公告）日：2012-10-04

  A cationic star polymer is disclosed of the general formula (1): I′P′] w′ (1), wherein w′ is a positive number greater than or equal to 3, I′ is a dendritic polyester core covalently linked to w′ independent peripheral linear cationic polymer chains P′. Each of the chains P′ comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.

  公开了一种阳离子星形聚合物，其一般式为（1）：I′P′]w′（1），其中w′是大于或等于3的正数，I′是一个树枝状聚酯核心，与w′个独立的外周线性阳离子聚合物链P′共价连接。每个链P′包括一个阳离子重复单元，包括i）从群组中选择的骨架功能基，该群组包括脂肪族碳酸酯，脂肪族酯，脂肪族氨基甲酸酯，脂肪族脲，脂肪族硫脲酸酯，脂肪族二硫代碳酸酯及其组合物，以及ii）包括季铵基团的侧链。季铵基团包括一个二价亚甲基基团，直接共价连接到i）一个正电荷氮和ii）一个芳香环。
• SILOXANE POLYMER CONTAINING TETHERED FLUOROQUINOLONE
  申请人：Stafslien Shane Jeremy

  公开号：US20120046313A1

  公开（公告）日：2012-02-23

  A polymer that is a polysiloxane polymer has fluoroquinolone antibiotic groups, or pharmaceutically acceptable salts thereof, attached via linkers. The linkers may be hydrolytically labile thereby providing a manner of releasing the fluoroquinolone antibiotic from the polymer.

  这是一种聚硅氧烷聚合物，通过连接剂连接了氟喹诺酮类抗生素基团或其药学上可接受的盐。连接剂可能是水解易裂的，从而提供了一种从聚合物中释放氟喹诺酮类抗生素的方法。