(Diethoxyphosphoryl)methyl 2-bromo-2-methylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (Diethoxyphosphoryl)methyl 2-bromo-2-methylpropanoate
• 英文别名: diethoxyphosphorylmethyl 2-bromo-2-methylpropanoate
• 化学式: C₉H₁₈BrO₅P
• 分子量: 317.11
• InChiKey: LHAQQKNVOHIBBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• MULTI-FUNCTIONAL SURFACE COATING OF IMPLANTS
  申请人：University of Massachusetts Medical School

  公开号：EP2925378A1

  公开（公告）日：2015-10-07
• COMPOSITIONS FOR SURFACE MINERALIZATION
  申请人：University of Massachusetts Medical School

  公开号：EP3139971B1

  公开（公告）日：2020-08-19
• COMPOSITIONS AND METHODS FOR SURFACE MINERALIZATION
  申请人：University of Massachusetts Medical School

  公开号：EP3139971A1

  公开（公告）日：2017-03-15
• US9943624B2
  申请人：——

  公开号：US9943624B2

  公开（公告）日：2018-04-17
• [EN] MULTI-FUNCTIONAL SURFACE COATING OF IMPLANTS<br/>[FR] REVÊTEMENT DE SURFACE MULTIFONCTIONNEL POUR IMPLANTS
  申请人：UNIV MASSACHUSETTS MEDICAL

  公开号：WO2014085275A1

  公开（公告）日：2014-06-05

  The invention provides novel surface coatings having surface polymer brushes with zwitterionic and antibiotics-conjugated side chains and synergistic anti-fouling and bactericidal properties. The surface coatings may be prepared using highly efficient surface-initiated "living" polymerization. The design of the surface polymer brushes are highly modular, allowing independent tuning of the anti-fouling and bactericidal properties, e.g., by varying the chemical nature of the zwitterionic motif and the antibiotic agent, the chemistry through which the antibiotic agent is conjugated to the polymer side chains, the molecular weight of the polymer brushes (e.g., thickness of coating and density of respective functional motifs), and the spatial arrangement of the respective functional motifs (e.g., homopolymers, block copolymers, random copolymers) to achieve optimal and sustained anti-infection outcome for a given application.