2-((2-Amino-5-cyano-6-(methylthio)pyrimidin-4-yl)thio)-N-(benzo[d]thiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-((2-Amino-5-cyano-6-(methylthio)pyrimidin-4-yl)thio)-N-(benzo[d]thiazol-2-yl)acetamide
• 英文别名: 2-(2-amino-5-cyano-6-methylsulfanylpyrimidin-4-yl)sulfanyl-N-(1,3-benzothiazol-2-yl)acetamide
• 化学式: C₁₅H₁₂N₆OS₃
• 分子量: 388.5
• InChiKey: PCILYMWQEGDZQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  196
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• P70S6 Kinase Modulators And Method Of Use
  申请人：Cheng Wei

  公开号：US20070208020A1

  公开（公告）日：2007-09-06

  The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

  本发明提供了用于抑制激酶的化合物和方法，更具体地是p70S6激酶。本发明提供了用于调节蛋白激酶酶活性以调节细胞活动的化合物，例如增殖、分化、程序性细胞死亡、迁移、化学侵袭和代谢。本发明的化合物抑制、调节和/或调节与上述细胞活动相关的激酶受体信号转导途径，并且本发明包括含有这些化合物的组合物以及使用它们治疗激酶依赖性疾病和病况的方法。
• P70S6 Kinase Modulators and Method of Use
  申请人：Cheng Wei

  公开号：US20110021525A1

  公开（公告）日：2011-01-27

  The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

  本发明提供了抑制激酶（更具体地说是p70S6激酶）的化合物和方法。本发明提供了用于调节蛋白激酶酶活性以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移、化学入侵和代谢）的化合物。本发明的化合物抑制、调节和/或调节与上述细胞活动相关的激酶受体信号转导途径，并包括含有这些化合物的组合物和使用它们治疗激酶依赖性疾病和病况的方法。
• EP1678168A4
  申请人：——

  公开号：EP1678168A4

  公开（公告）日：2008-09-24
• P70S6 KINASE MODULATORS AND METHOD OF USE
  申请人：Exelixis, Inc.

  公开号：EP1678168B1

  公开（公告）日：2012-07-11
• JP2007527413A
  申请人：——

  公开号：JP2007527413A

  公开（公告）日：2007-09-27