2-(3,4-dihydroxyphenyl)ethyl (Z)-hept-4-enoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(3,4-dihydroxyphenyl)ethyl (Z)-hept-4-enoate
• 化学式: C₁₅H₂₀O₄
• 分子量: 264.32
• InChiKey: ZUUPMIRPGIIPMA-ARJAWSKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition
  申请人：McCord Darlene E.

  公开号：US10231939B2

  公开（公告）日：2019-03-19

  Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.

  本研究公开了由含羟基酪醇的制剂组成的组合物和由羟基酪醇和/或油菜素及化疗药物组成的治疗方案。组合物和/或治疗方案可选择包括服用维生素、矿物质和抗氧化剂。本发明提供了使用这些组合物和治疗方案治疗受试者疾病（如恶性肿瘤）的方法，以及诱导或增强血管生成、治疗或预防氧化应激、治疗或预防高血糖诱导的功能障碍、治疗或预防化疗诱导的功能障碍以及提高细胞活力的方法。还提供了羟基酪醇组合物在各种癌症中用于抑制赖氨酸特异性去甲基化酶 1（LSD1）的各种方法。
• HYDROXYTYROSOL AND OLEUROPEIN COMPOSITIONS FOR INDUCTION OF DNA DAMAGE, CELL DEATH AND LSD1 INHIBITION
  申请人：McCord Darlene E.

  公开号：US20140155339A1

  公开（公告）日：2014-06-05

  Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided.
• US9144555B2
  申请人：——

  公开号：US9144555B2

  公开（公告）日：2015-09-29