Methyl 8-chloro-3-[2-(4-methylphenoxy)ethyl]imidazo[1,2-a]pyrazine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: Methyl 8-chloro-3-[2-(4-methylphenoxy)ethyl]imidazo[1,2-a]pyrazine-2-carboxylate
• 英文别名: methyl 8-chloro-3-[2-(4-methylphenoxy)ethyl]imidazo[1,2-a]pyrazine-2-carboxylate
• 化学式: C₁₇H₁₆ClN₃O₃
• 分子量: 345.8
• InChiKey: VSFIGYFVKJZSFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  65.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  申请人：Hanney Barbara

  公开号：US20140155413A1

  公开（公告）日：2014-06-05

  The present invention is directed to compounds of formula I and 1a: which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

  本发明涉及公式I和1a的化合物，它们是肌动蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此在治疗疼痛、炎症、癌症、再狭窄、动脉粥样硬化、银屑病、血栓形成、与失髓鞘或脱髓鞘有关的疾病、紊乱、损伤或功能障碍，或与神经生长因子（NGF）受体TrkA的异常活动有关的疾病或紊乱的治疗中有用。
• US9102673B2
  申请人：——

  公开号：US9102673B2

  公开（公告）日：2015-08-11